The Effect of Fluoxetine Combined with Repetitive Transcranial Magnetic Stimulation on the Psychological Emotions and Cognitive and Neurological Functions of Acute Post-stroke Depression Patients

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2021 Nov 17

PMID 34786118

Citations 7

Authors

Fangzhou Yu

Ru He

Affiliations

Soon will be listed here.

Abstract

Objective: This research was designed to probe into the effects of fluoxetine combined with repetitive transcranial magnetic stimulation (rTMS) on the psychological emotions and the cognitive and neurological functions of acute post-stroke depression patients.

Methods: This experiment recruited 115 acute post-stroke depression patients who were treated in our hospital from February 2018 to April 2020 as the study cohort. 55 of the patients were treated with fluoxetine, and 60 were treated with fluoxetine combined with rTMS. Both groups were treated for 2 months. The self-rating anxiety scale (SAS), the self-rating depression scale (SDS), the National Institutes of Health stroke scale (NIHSS), the mini mental state scale (MMSE), the Barthel index, and the quality of life scale (SF-36) scores were observed.

Results: Compared with the control group (CG), the SAS, SDS, and NIHSS scores in the research group (RG) decreased, while the MMSE and Barthel index scores increased ( < 0.05). After the treatment, the SF-36 scores in the RG were higher than they were in the CG ( < 0.05).

Conclusion: Fluoxetine combined with rTMS can effectively improve the psychological emotions and the cognitive and neurological functions of acute post-stroke depression patients, so it is worthy of clinical promotion.

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