A Paradoxical Role for Sestrin 2 Protein in Tumor Suppression and Tumorigenesis

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2021 Nov 17

PMID 34784907

Citations 12

Authors

Junsheng Qu

Moyi Luo

Jingwen Zhang

Fang Han

Ningning Hou

Ruiyan Pan

Xiaodong Sun

Affiliations

Soon will be listed here.

Abstract

Sestrin 2, a highly conserved stress-induced protein, participates in the pathological processes of metabolic and age-related diseases. This p53-inducible protein also regulates cell growth and metabolism, which is closely related to malignant tumorigenesis. Sestrin 2 was reported to regulate various cellular processes, such as tumor cell proliferation, invasion and metastasis, apoptosis, anoikis resistance, and drug resistance. Although sestrin 2 is associated with colorectal, lung, liver, and other cancers, sestrin 2 expression varies among different types of cancer, and the effects and mechanisms of action of this protein are also different. Sestrin 2 was considered a tumor suppressor gene in most studies, whereas conflicting reports considered sestrin 2 an oncogene. Thus, this review aims to examine the literature regarding sestrin 2 in various cancers, summarize its roles in suppression and tumorigenesis, discuss potential mechanisms in the regulation of cancer, and provide a basis for follow-up research and potential cancer treatment development.

Citing Articles

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Evaluation of Serum Sestrin 2 Levels in Patients Diagnosed with Endometrial Polyps and Uterine Leiomyomas.

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Sestrin2 in diabetes and diabetic complications.

Zhang X, Luo Z, Li J, Lin Y, Li Y, Li W Front Endocrinol (Lausanne). 2023; 14:1274686.

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