T-cell-receptor Beta- and I-A Beta-chain Genes of Normal SWR Mice Are Linked with the Development of Lupus Nephritis in NZB X SWR Crosses

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1987 Oct 1

PMID 3477811

Citations 18

Authors

S Ghatak

K Sainis

F L Owen

S K Datta

Affiliations

Soon will be listed here.

Abstract

The incidence of nephritis in autoimmune New Zealand Black (NZB) mice is low, but when they are crossed with normal SWR mice, almost 100% of the female F1 hybrids (SNF1) develop lethal glomerulonephritis. To define the contribution of the normal SWR strain to the development of nephritis, we analyzed the association of the I-A beta-chain gene of Ia-encoding region, the T-cell-receptor beta (TcR beta)-chain gene, and immunoglobulin heavy-chain allotype (IgH) with the development of lupus nephritis in 165 NZB X SWR crosses. We found that genes linked to the TcR and Ir gene loci of the normal SWR mice interacted with NZB-derived genes, leading to the development of accelerated and severe nephritis in the NZB X SWR crosses.

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