Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Nov 15

PMID 34778084

Citations 8

Authors

Shanshan Chen

Yi Fang

Lingyu Sun

Ruonan He

Beihui He

Shuo Zhang

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have recently drawn great attention for their potential roles in the different stages of CRC formation, invasion, and progression, including regulation of molecular signaling pathways, apoptosis, autophagy, angiogenesis, tumor metabolism, immunological responses, cell cycle, and epithelial-mesenchymal transition (EMT). This review aims to discuss the potential mechanisms of several oncogenic lncRNAs, as well as several suppressor lncRNAs, in CRC occurrence and development to aid in the discovery of new methods for CRC diagnosis, treatment, and prognosis assessment.

Citing Articles

LncRNA MALAT1 as diagnostic and prognostic biomarker in colorectal cancers: A systematic review and meta-analysis.

Masrour M, Khanmohammadi S, Habibzadeh A, Fallahtafti P PLoS One. 2024; 19(10):e0308009.

PMID: 39471147 PMC: 11521308. DOI: 10.1371/journal.pone.0308009.

Anti-angiogenesis in colorectal cancer therapy.

Yang Z, Zhang X, Bai X, Xi X, Liu W, Zhong W Cancer Sci. 2024; 115(3):734-751.

PMID: 38233340 PMC: 10921012. DOI: 10.1111/cas.16063.

MBNL1‑AS1 attenuates tumor cell proliferation by regulating the miR‑29c‑3p/BVES signal in colorectal cancer.

Chen W, Zhang X, Zhao Z, Che X Oncol Rep. 2023; 50(4).

PMID: 37711058 PMC: 10523431. DOI: 10.3892/or.2023.8628.

Interaction of lncRNAs with mTOR in colorectal cancer: a systematic review.

Moslehian M, Shabkhizan R, Asadi M, Bazmani A, Mahdipour M, Haiaty S BMC Cancer. 2023; 23(1):512.

PMID: 37280524 PMC: 10243085. DOI: 10.1186/s12885-023-11008-9.

Analysis of LINC01314 and miR-96 Expression in Colorectal Cancer Patients via Tissue Microarray-Based Fluorescence Hybridization.

Zhang R, Zhang G, Li B, Wang J, Wang J, Che J Dis Markers. 2022; 2022:5378963.

PMID: 36246563 PMC: 9568347. DOI: 10.1155/2022/5378963.

References

Wang W, Martindale J, Yang X, Chrest F, Gorospe M . Increased stability of the p16 mRNA with replicative senescence. EMBO Rep. 2005; 6(2):158-64. PMC: 1299256. DOI: 10.1038/sj.embor.7400346. View

Na H, Surh Y . Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1. Free Radic Biol Med. 2013; 67:353-65. DOI: 10.1016/j.freeradbiomed.2013.10.819. View

Chase A, Cross N . Aberrations of EZH2 in cancer. Clin Cancer Res. 2011; 17(9):2613-8. DOI: 10.1158/1078-0432.CCR-10-2156. View

Lan Y, Xiao X, He Z, Luo Y, Wu C, Li L . Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer. Nucleic Acids Res. 2018; 46(11):5809-5821. PMC: 6009600. DOI: 10.1093/nar/gky214. View

Doherty J, Cleveland J . Targeting lactate metabolism for cancer therapeutics. J Clin Invest. 2013; 123(9):3685-92. PMC: 3754272. DOI: 10.1172/JCI69741. View

Liu Q, Huang J, Zhou N, Zhang Z, Zhang A, Lu Z . LncRNA loc285194 is a p53-regulated tumor suppressor. Nucleic Acids Res. 2013; 41(9):4976-87. PMC: 3643595. DOI: 10.1093/nar/gkt182. View

Taniue K, Kurimoto A, Takeda Y, Nagashima T, Okada-Hatakeyama M, Katou Y . -TCF3 complex is required for the tumorigenicity of colorectal cancer cells. Proc Natl Acad Sci U S A. 2016; 113(45):12739-12744. PMC: 5111701. DOI: 10.1073/pnas.1605938113. View

Soleimani A, Rahmani F, Ferns G, Ryzhikov M, Avan A, Hassanian S . Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer. Gene. 2019; 726:144132. DOI: 10.1016/j.gene.2019.144132. View

Tsavaris N, Lazaris A, Kosmas C, Gouveris P, Kavantzas N, Kopterides P . Topoisomerase I and IIalpha protein expression in primary colorectal cancer and recurrences following 5-fluorouracil-based adjuvant chemotherapy. Cancer Chemother Pharmacol. 2008; 64(2):391-8. PMC: 2688619. DOI: 10.1007/s00280-008-0886-4. View

10.

Ou C, Sun Z, Li X, Li X, Ren W, Qin Z . MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer. Cancer Lett. 2017; 399:53-63. DOI: 10.1016/j.canlet.2017.04.011. View

11.

Takahashi K, Yan I, Wood J, Haga H, Patel T . Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy. Mol Cancer Res. 2014; 12(10):1377-87. PMC: 4201956. DOI: 10.1158/1541-7786.MCR-13-0636. View

12.

Whitesell L, Lindquist S . HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005; 5(10):761-72. DOI: 10.1038/nrc1716. View

13.

Lebedeva S, Jens M, Theil K, Schwanhausser B, Selbach M, Landthaler M . Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. Mol Cell. 2011; 43(3):340-52. DOI: 10.1016/j.molcel.2011.06.008. View

14.

Li X, Liu Y, Chen W, Fang Y, Xu H, Zhu H . TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer. Oncotarget. 2014; 5(19):9498-513. PMC: 4253449. DOI: 10.18632/oncotarget.2411. View

15.

Wang J, Lu T, Kung M, Yang Y, Yeh C, Tu Y . The Long Noncoding RNA LOC441461 (STX17-AS1) Modulates Colorectal Cancer Cell Growth and Motility. Cancers (Basel). 2020; 12(11). PMC: 7692211. DOI: 10.3390/cancers12113171. View

16.

Furfaro A, Traverso N, Domenicotti C, Piras S, Moretta L, Marinari U . The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance. Oxid Med Cell Longev. 2015; 2016:1958174. PMC: 4677237. DOI: 10.1155/2016/1958174. View

17.

Ishiwata T . Cancer stem cells and epithelial-mesenchymal transition: Novel therapeutic targets for cancer. Pathol Int. 2016; 66(11):601-608. DOI: 10.1111/pin.12447. View

18.

Silva-Fisher J, Dang H, White N, Strand M, Krasnick B, Rozycki E . Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression. Nat Commun. 2020; 11(1):2156. PMC: 7195452. DOI: 10.1038/s41467-020-15547-8. View

19.

Tsai K, Lo Y, Liu H, Yeh C, Chen Y, Hsu C . Linc00659, a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer. Mol Cancer. 2018; 17(1):72. PMC: 5845323. DOI: 10.1186/s12943-018-0821-1. View

20.

Song N, Zhong J, Hu Q, Gu T, Yang B, Zhang J . FGF18 Enhances Migration and the Epithelial-Mesenchymal Transition in Breast Cancer by Regulating Akt/GSK3β/Β-Catenin Signaling. Cell Physiol Biochem. 2018; 49(3):1019-1032. DOI: 10.1159/000493286. View