Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Nov 15

PMID 34778061

Citations 2

Authors

Qin Dang

Zaoqu Liu

Shengyun Hu

Zhuang Chen

Lingfang Meng

Junhong Hu

Guixian Wang

Weitang Yuan

Xinwei Han

Lifeng Li

Zhenqiang Sun

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC), a seriously threat that endangers public health, has a striking tendency to relapse and metastasize. Redox-related signaling pathways have recently been extensively studied in cancers. However, the study and potential role of redox in CRC remain unelucidated. We developed and validated a risk model for prognosis and recurrence prediction in CRC patients identifying gene signatures driven by redox-related signaling pathways. The redox-driven prognostic signature (RDPS) was demonstrated to be an independent risk factor for patient survival (including OS and RFS) in four public cohorts and one clinical in-house cohort. Additionally, there was an intimate association between the risk score and tumor immune infiltration, with higher risk score accompanied with less immune cell infiltration. In this study, we used redox-related factors as an entry point, which may provide a broader perspective for prognosis prediction in CRC and have the potential to provide more promising evidence for immunotherapy.

Citing Articles

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PMID: 35833141 PMC: 9271859. DOI: 10.3389/fimmu.2022.910582.

Development and Validation of an 8-Gene Signature to Improve Survival Prediction of Colorectal Cancer.

Zhou L, Yu Y, Wen R, Zheng K, Jiang S, Zhu X Front Oncol. 2022; 12:863094.

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