Development of an Enolate Alkynylation Approach Towards the Synthesis of the Taiwanschirin Natural Products

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2021 Nov 15

PMID 34777757

Citations 2

Authors

Maxwell B Haughey

Kirsten E Christensen

Darren L Poole

Timothy J Donohoe

Affiliations

Soon will be listed here.

Abstract

Through the use of model studies, an approach was conceived towards the synthesis of the taiwanschirin family of natural products. These are structurally complex compounds which represent highly challenging and biologically active targets for total synthesis. This work describes a successful synthesis of the complex taiwanschirin fused [8,6,5] core through a novel alkynylation reaction coupled with an intramolecular Heck reaction used to construct the 8-membered ring.

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