Neural Circuits for Social Interactions: From Microcircuits to Input-Output Circuits

Overview

Journal Front Neural Circuits

Date 2021 Nov 15

PMID 34776877

Citations 17

Authors

Sen Xu

Ming Jiang

Xia Liu

Yahan Sun

Liang Yang

Qinghu Yang

Zhantao Bai

Affiliations

Soon will be listed here.

Abstract

Social behaviors entail responses to social information and requires the perception and integration of social cues through a complex cognition process that involves attention, memory, motivation, and emotion. Neurobiological and molecular mechanisms underlying social behavior are highly conserved across species, and inter- and intra-specific variability observed in social behavior can be explained to large extent by differential activity of a conserved neural network. However, neural microcircuits and precise networks involved in social behavior remain mysterious. In this review, we summarize the microcircuits and input-output circuits on the molecular, cellular, and network levels of different social interactions, such as social exploration, social hierarchy, social memory, and social preference. This review provides a broad view of how multiple microcircuits and input-output circuits converge on the medial prefrontal cortex, hippocampus, and amygdala to regulate complex social behaviors, as well as a potential novel view for better control over pathological development.

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