MiR-6745-TIMP1 Axis Inhibits Cell Growth and Metastasis in Gastric Cancer

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2021 Nov 14

PMID 34775375

Citations 13

Authors

Hui Liu

Yuan Xiang

Qi-Bei Zong

Xiao-Yu Zhang

Zhi-Wen Wang

Shi-Qiang Fang

Tong-Cun Zhang

Xing-Hua Liao

Affiliations

Soon will be listed here.

Abstract

Tissue inhibitor matrix metalloproteinase 1 (TIMP1) has been reported to act as a tumor oncogene in colon cancer. However, little is known about the biological role of TIMP1 in gastric cancer. In this study, we found that the expression of TIMP1 in GC tissues was upregulated compared with the normal gastric tissues. TIMP1 was confirmed as a direct target of miR-6745 and silencing TIMP1 mimicked the effects of miR-6745 in GC cells. Further mechanism studies have shown that miR-6745 inhibits the Wnt/β-catenin pathway by targeting TIMP1, thereby inhibiting cell proliferation, migration and invasion. In addition, through the analysis of GC tissues, a negative correlation between miR-6745 and TIMP1 was found in 42 GC tissues. Our findings indicate that the miR-6745-TIMP1 axis regulates Wnt/βcatenin signaling and participates in GC tumorigenesis and provide a potential therapeutic target for preventing GC progression.

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