» Articles » PMID: 34773047

Fatigue After Acquired Brain Injury Impacts Health-related Quality of Life: an Exploratory Cohort Study

Overview
Journal Sci Rep
Specialty Science
Date 2021 Nov 13
PMID 34773047
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

This study aimed to identify the consequences of fatigue, fatigability, cognitive and executive functioning, and emotional state on health-related quality of life (HRQoL) in a clinical group of outpatients after acquired brain injury (ABI). This cross-sectional retrospective study included assessing outpatients at a rehabilitation clinic with WAIS-III working memory and coding subtests, and self-rating scales (Fatigue Impact Scale, Dysexecutive Questionnaire, Hospital Anxiety and Depression Scale, and the dimension of health-related quality of life from EQ-5D-3L). The predictive variables were investigated using a binary logistic regression with HRQoL as the dependent variable. Descriptive statistics and correlations were analyzed. Participants reported a lower than average HRQoL (95%), fatigue (90%), and executive dysfunction (75%). Fatigue had a significant impact and explained 20-33% of the variance in HRQoL with a moderate significance on depression (p = 0.579) and executive dysfunction (p = 0.555). Cognitive and executive function and emotional state showed no association with HRQoL. A lower HRQoL, as well as fatigue and cognitive and executive dysfunctions, are common after ABI, with fatigue is a partial explanation of a lower HRQoL.

Citing Articles

More absolute moderate-to-vigorous physical activity is associated with better health-related quality of life in outpatients with an acquired brain injury.

MacDonald E, Pellerine L, Miller K, Frayne R, OBrien M Front Rehabil Sci. 2024; 5:1427446.

PMID: 39713263 PMC: 11659261. DOI: 10.3389/fresc.2024.1427446.


Neuropsychological outcome after cardiac arrest: results from a sub-study of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial.

Nordstrom E, Vestberg S, Evald L, Mion M, Segerstrom M, Ullen S Crit Care. 2023; 27(1):328.

PMID: 37633944 PMC: 10463667. DOI: 10.1186/s13054-023-04617-0.


Psychosocial functioning mediates change in motor and cognitive function throughout neurorehabilitation for adults with acquired brain injury (ABI-RESTaRT).

Mann G, Troeung L, Singh K, Reddell C, Martini A Neurol Sci. 2023; 44(7):2401-2411.

PMID: 36780031 PMC: 10257595. DOI: 10.1007/s10072-023-06645-8.


The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer: A DCCSS LATER Study.

Penson A, Walraven I, Bronkhorst E, Maurice-Stam H, Grootenhuis M, van der Heiden-van der Loo M Cancers (Basel). 2022; 14(12).

PMID: 35740518 PMC: 9221067. DOI: 10.3390/cancers14122851.

References
1.
Flensner G, Ek A, Soderhamn O . Reliability and validity of the Swedish version of the Fatigue Impact Scale (FIS). Scand J Occup Ther. 2006; 12(4):170-80. DOI: 10.1080/11038120510031806. View

2.
Kluger B, Krupp L, Enoka R . Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy. Neurology. 2013; 80(4):409-16. PMC: 3589241. DOI: 10.1212/WNL.0b013e31827f07be. View

3.
Ramirez-Moreno J, Munoz-Vega P, Alberca S, Peral-Pacheco D . Health-Related Quality of Life and Fatigue After Transient Ischemic Attack and Minor Stroke. J Stroke Cerebrovasc Dis. 2019; 28(2):276-284. DOI: 10.1016/j.jstrokecerebrovasdis.2018.09.046. View

4.
Fisk J, Ritvo P, Ross L, Haase D, Marrie T, Schlech W . Measuring the functional impact of fatigue: initial validation of the fatigue impact scale. Clin Infect Dis. 1994; 18 Suppl 1:S79-83. DOI: 10.1093/clinids/18.supplement_1.s79. View

5.
Teasell R, Bayona N, Marshall S, Cullen N, Bayley M, Chundamala J . A systematic review of the rehabilitation of moderate to severe acquired brain injuries. Brain Inj. 2007; 21(2):107-12. DOI: 10.1080/02699050701201524. View