In Vitro and In Silico Interaction Studies with Red Wine Polyphenols Against Different Proteins from Human Serum

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Nov 13

PMID 34771095

Citations 7

Authors

Raja Mohamed Beema Shafreen

Selvaraj Alagu Lakshmi

Shunmugiah Karutha Pandian

Young-Mo Kim

Joseph Deutsch

Elena Katrich

Shela Gorinstein

Affiliations

Soon will be listed here.

Abstract

Previous reports have shown that consumption of wine has several health benefits; however, there are different types of wine. In the present study, red wines were investigated for their compositions of active ingredients. The interaction of each component in terms of its binding mode with different serum proteins was unraveled, and the components were implicated as drug candidates in clinical settings. Overall, the study indicates that red wines have a composition of flavonoids, non-flavonoids, and phenolic acids that can interact with the key regions of proteins to enhance their biological activity. Among them, rutin, resveratrol, and tannic acid have shown good binding affinity and possess beneficial properties that can enhance their role in clinical applications.

Citing Articles

Characterization of Bioactivity of Selective Molecules in Fruit Wines by FTIR and NMR Spectroscopies, Fluorescence and Docking Calculations.

Kim Y, Lubinska-Szczygel M, Park Y, Deutsch J, Ezra A, Luksrikul P Molecules. 2023; 28(16).

PMID: 37630288 PMC: 10457986. DOI: 10.3390/molecules28166036.

Red Wine and Sexual Function in Men: An Original Point of View.

Basile L, Condorelli R, Calogero A, Cannarella R, Barbagallo F, Crafa A J Clin Med. 2023; 12(12).

PMID: 37373577 PMC: 10298949. DOI: 10.3390/jcm12123883.

Metabolomics-Based Analyses of Dynamic Changes in Flavonoid Profiles in the Black Mulberry Winemaking Process.

Qin Y, Xu H, Chen Y, Lei J, Sun J, Zhao Y Foods. 2023; 12(11).

PMID: 37297465 PMC: 10252360. DOI: 10.3390/foods12112221.

Food Antioxidants and Their Interaction with Human Proteins.

Nedic O, Penezic A, Minic S, Radomirovic M, Nikolic M, Cirkovic Velickovic T Antioxidants (Basel). 2023; 12(4).

PMID: 37107190 PMC: 10135064. DOI: 10.3390/antiox12040815.

HPLC Analysis of Polyphenols Derived from Hungarian Aszú from Tokaj Wine Region and Its Effect on Inflammation in an In Vitro Model System of Endothelial Cells.

Markovics A, Csige L, Szollosi E, Matyi H, Lukacs A, Perez N Int J Mol Sci. 2023; 24(7).

PMID: 37047095 PMC: 10094128. DOI: 10.3390/ijms24076124.

References

Pinto A, Nascimento J, Vitoria da Silva Sobral R, Amorim E, Silva R, Lima Leite A . Tannic acid as a precipitating agent of human plasma proteins. Eur J Pharm Sci. 2019; 138:105018. DOI: 10.1016/j.ejps.2019.105018. View

Pozo-Bayon M, Hernandez M, Martin-Alvarez P, Polo M . Study of low molecular weight phenolic compounds during the aging of sparkling wines manufactured with red and white grape varieties. J Agric Food Chem. 2003; 51(7):2089-95. DOI: 10.1021/jf021017z. View

Xiao J, Zhao Y, Wang H, Yuan Y, Yang F, Zhang C . Noncovalent interaction of dietary polyphenols with common human plasma proteins. J Agric Food Chem. 2011; 59(19):10747-54. DOI: 10.1021/jf2029829. View

Tekos F, Makri S, Skaperda Z, Patouna A, Terizi K, Kyriazis I . Assessment of Antioxidant and Antimutagenic Properties of Red and White Wine Extracts In Vitro. Metabolites. 2021; 11(7). PMC: 8304343. DOI: 10.3390/metabo11070436. View

Roumenina L, Ruseva M, Zlatarova A, Ghai R, Kolev M, Olova N . Interaction of C1q with IgG1, C-reactive protein and pentraxin 3: mutational studies using recombinant globular head modules of human C1q A, B, and C chains. Biochemistry. 2006; 45(13):4093-104. PMC: 3874390. DOI: 10.1021/bi052646f. View

Wu Y, Zhong L, Yu Z, Qi J . Anti-neuroinflammatory effects of tannic acid against lipopolysaccharide-induced BV2 microglial cells via inhibition of NF-κB activation. Drug Dev Res. 2019; 80(2):262-268. DOI: 10.1002/ddr.21490. View

Ramdani L, Bachari K . Potential therapeutic effects of Resveratrol against SARS-CoV-2. Acta Virol. 2020; 64(3):276-280. DOI: 10.4149/av_2020_309. View

Chu X, Guo Y, Xu B, Li W, Lin Y, Sun X . Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. PLoS One. 2015; 10(12):e0143797. PMC: 4666621. DOI: 10.1371/journal.pone.0143797. View

Mondal P, Bose A . Spectroscopic overview of quercetin and its Cu(II) complex interaction with serum albumins. Bioimpacts. 2019; 9(2):115-121. PMC: 6637219. DOI: 10.15171/bi.2019.15. View

10.

Rakshit S, Shukla P, Verma A, Nirala S, Bhadauria M . Protective role of rutin against combined exposure to lipopolysaccharide and D-galactosamine-induced dysfunctions in liver, kidney, and brain: Hematological, biochemical, and histological evidences. J Food Biochem. 2021; 45(2):e13605. DOI: 10.1111/jfbc.13605. View

11.

Dong G, Liu H, Yu X, Zhang X, Lu H, Zhou T . Antimicrobial and anti-biofilm activity of tannic acid against Staphylococcus aureus. Nat Prod Res. 2017; 32(18):2225-2228. DOI: 10.1080/14786419.2017.1366485. View

12.

Snopek L, Mlcek J, Sochorova L, Baron M, Hlavacova I, Jurikova T . Contribution of Red Wine Consumption to Human Health Protection. Molecules. 2018; 23(7). PMC: 6099584. DOI: 10.3390/molecules23071684. View

13.

Kaur G, Rao L, Agrawal A, Pendurthi U . Effect of wine phenolics on cytokine-induced C-reactive protein expression. J Thromb Haemost. 2007; 5(6):1309-17. PMC: 2831220. DOI: 10.1111/j.1538-7836.2007.02527.x. View

14.

Kaczmarek B . Tannic Acid with Antiviral and Antibacterial Activity as A Promising Component of Biomaterials-A Minireview. Materials (Basel). 2020; 13(14). PMC: 7412100. DOI: 10.3390/ma13143224. View

15.

Tedesco I, Spagnuolo C, Russo G, Russo M, Cervellera C, Moccia S . The Pro-Oxidant Activity of Red Wine Polyphenols Induces an Adaptive Antioxidant Response in Human Erythrocytes. Antioxidants (Basel). 2021; 10(5). PMC: 8158335. DOI: 10.3390/antiox10050800. View

16.

Ter Ellen B, Dinesh Kumar N, Bouma E, Troost B, van de Pol D, van der Ende-Metselaar H . Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air-Liquid Interface Cultured Human Primary Bronchial Epithelial Cells. Viruses. 2021; 13(7). PMC: 8309965. DOI: 10.3390/v13071335. View

17.

Benzie I, Strain J . The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem. 1996; 239(1):70-6. DOI: 10.1006/abio.1996.0292. View

18.

Castaldo L, Narvaez A, Izzo L, Graziani G, Gaspari A, Di Minno G . Red Wine Consumption and Cardiovascular Health. Molecules. 2019; 24(19). PMC: 6804046. DOI: 10.3390/molecules24193626. View

19.

Ren B, Huang W, Akesson B, Ladenstein R . The crystal structure of seleno-glutathione peroxidase from human plasma at 2.9 A resolution. J Mol Biol. 1997; 268(5):869-85. DOI: 10.1006/jmbi.1997.1005. View

20.

Song J, Yu Y, Xing R, Guo X, Liu D, Wei J . Unglycosylated recombinant human glutathione peroxidase 3 mutant from Escherichia coli is active as a monomer. Sci Rep. 2014; 4:6698. PMC: 4204031. DOI: 10.1038/srep06698. View