Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Nov 13

PMID 34768894

Citations 15

Authors

Ewa Szczepanska-Sadowska

Agnieszka Wsol

Agnieszka Cudnoch-Jedrzejewska

Tymoteusz Zera

Affiliations

Soon will be listed here.

Abstract

The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, soma, and dendrites and modulate the excitability of other neuroregulatory pathways. The synthesis and action of OXY and AVP in the peripheral organs (eye, heart, gastrointestinal system) is being investigated. The secretion of OXY and AVP is influenced by changes in body fluid osmolality, blood volume, blood pressure, hypoxia, and stress. Vasopressin interacts with three subtypes of receptors: V1aR, V1bR, and V2R whereas oxytocin activates its own OXTR and V1aR receptors. AVP and OXY receptors are present in several regions of the brain (cortex, hypothalamus, pons, medulla, and cerebellum) and in the peripheral organs (heart, lungs, carotid bodies, kidneys, adrenal glands, pancreas, gastrointestinal tract, ovaries, uterus, thymus). Hypertension, myocardial infarction, and coexisting factors, such as pain and stress, have a significant impact on the secretion of oxytocin and vasopressin and on the expression of their receptors. The inappropriate regulation of oxytocin and vasopressin secretion during ischemia, hypoxia/hypercapnia, inflammation, pain, and stress may play a significant role in the pathogenesis of cardiovascular diseases.

Citing Articles

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Molecular Interaction Between Vasopressin and Insulin in Regulation of Metabolism: Impact on Cardiovascular and Metabolic Diseases.

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The Interaction of Vasopressin with Hormones of the Hypothalamo-Pituitary-Adrenal Axis: The Significance for Therapeutic Strategies in Cardiovascular and Metabolic Diseases.

Szczepanska-Sadowska E, Czarzasta K, Bogacki-Rychlik W, Kowara M Int J Mol Sci. 2024; 25(13).

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References

Griffiths P, Lolait S, Harris L, Paton J, OCarroll A . Vasopressin V1a receptors mediate the hypertensive effects of [Pyr ]apelin-13 in the rat rostral ventrolateral medulla. J Physiol. 2017; 595(11):3303-3318. PMC: 5451710. DOI: 10.1113/JP274178. View

Stoop R . Neuromodulation by oxytocin and vasopressin. Neuron. 2012; 76(1):142-59. DOI: 10.1016/j.neuron.2012.09.025. View

Lozic M, Sarenac O, Murphy D, Japundzic-Zigon N . Vasopressin, Central Autonomic Control and Blood Pressure Regulation. Curr Hypertens Rep. 2018; 20(2):11. DOI: 10.1007/s11906-018-0811-0. View

Szczepanska-Sadowska E, Zera T, Sosnowski P, Cudnoch-Jedrzejewska A, Puszko A, Misicka A . Vasopressin and Related Peptides; Potential Value in Diagnosis, Prognosis and Treatment of Clinical Disorders. Curr Drug Metab. 2017; 18(4):306-345. DOI: 10.2174/1389200218666170119145900. View

Lolait S, OCarroll A, Mahan L, Felder C, Button D, Young 3rd W . Extrapituitary expression of the rat V1b vasopressin receptor gene. Proc Natl Acad Sci U S A. 1995; 92(15):6783-7. PMC: 41413. DOI: 10.1073/pnas.92.15.6783. View

Szczepanska-Sadowska E, Brzezinski M . Interaction between effects of insulin and vasopressin on renal excretion of water and sodium in rats. Horm Metab Res. 1982; 14(4):175-9. DOI: 10.1055/s-2007-1018962. View

Datta A, Yang C, Limbutara K, Chou C, Rinschen M, Raghuram V . PKA-independent vasopressin signaling in renal collecting duct. FASEB J. 2020; 34(5):6129-6146. PMC: 9200475. DOI: 10.1096/fj.201902982R. View

Reinstadler S, Klug G, Feistritzer H, Mayr A, Harrasser B, Mair J . Association of copeptin with myocardial infarct size and myocardial function after ST segment elevation myocardial infarction. Heart. 2013; 99(20):1525-9. DOI: 10.1136/heartjnl-2013-303975. View

Nickel C, Bingisser R, Morgenthaler N . The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department. BMC Med. 2012; 10:7. PMC: 3275505. DOI: 10.1186/1741-7015-10-7. View

10.

Gutkowska J, Broderick T, Bogdan D, Wang D, Lavoie J, Jankowski M . Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy. J Physiol. 2009; 587(Pt 19):4725-36. PMC: 2768025. DOI: 10.1113/jphysiol.2009.176461. View

11.

Jankowski M, Wang D, Hajjar F, Mukaddam-Daher S, McCANN S, Gutkowska J . Oxytocin and its receptors are synthesized in the rat vasculature. Proc Natl Acad Sci U S A. 2000; 97(11):6207-11. PMC: 18583. DOI: 10.1073/pnas.110137497. View

12.

Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg H, McCANN S . Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart. Proc Natl Acad Sci U S A. 1997; 94(21):11704-9. PMC: 23602. DOI: 10.1073/pnas.94.21.11704. View

13.

Liu J, Clarke I, Funder J, Engler D . Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged.... J Clin Invest. 1994; 93(4):1439-50. PMC: 294157. DOI: 10.1172/JCI117121. View

14.

Schrier R . Vasopressin and aquaporin 2 in clinical disorders of water homeostasis. Semin Nephrol. 2008; 28(3):289-96. PMC: 2587374. DOI: 10.1016/j.semnephrol.2008.03.009. View

15.

Raff H, SHINSAKO J, Keil L, Dallman M . Vasopressin, ACTH, and corticosteroids during hypercapnia and graded hypoxia in dogs. Am J Physiol. 1983; 244(5):E453-8. DOI: 10.1152/ajpendo.1983.244.5.E453. View

16.

Zhang R, Zhang H, Han J, Han S . Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders. Neurosci Bull. 2017; 33(2):238-246. PMC: 5360847. DOI: 10.1007/s12264-017-0120-7. View

17.

Norsk P . Influence of low- and high-pressure baroreflexes on vasopressin release in humans. Acta Endocrinol (Copenh). 1989; 121 Suppl 1:3-27. DOI: 10.1530/acta.0.1210003-a. View

18.

Gruber C, Muttenthaler M, Freissmuth M . Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors. Curr Pharm Des. 2010; 16(28):3071-88. PMC: 4939874. DOI: 10.2174/138161210793292474. View

19.

Wigger A, Sanchez M, Mathys K, Ebner K, Frank E, Liu D . Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Neuropsychopharmacology. 2003; 29(1):1-14. DOI: 10.1038/sj.npp.1300290. View

20.

Urbach J, Goldsmith S . Vasopressin antagonism in heart failure: a review of the hemodynamic studies and major clinical trials. Ther Adv Cardiovasc Dis. 2021; 15:1753944720977741. PMC: 7809578. DOI: 10.1177/1753944720977741. View