Mucoepidermoid Carcinoma: Evaluating the Prognostic Impact of Primary Tumor Site

Overview

Journal Oral Oncol

Publisher Elsevier

Specialty Dentistry

Date 2021 Nov 12

PMID 34768210

Citations 5

Authors

Ximena Mimica

Avery Yuan

Ashley Hay

Nora Katabi

Daniella Karassawa Zanoni

Cristina Valero

Jatin P Shah

Richard J Wong

Marc A Cohen

Snehal G Patel

Ian Ganly

Affiliations

Soon will be listed here.

Abstract

Material And Methods: This cohort identified 308 patients with MEC who underwent primary surgery between 1985 and 2015. Survival outcomes were determined using the Kaplan-Meier method. Hazard ratios for primary site were determined using the Cox proportional-hazards model.

Results: One hundred eighty (58%) patients were diagnosed with minor and 128 (42%) with major salivary gland cancer. Primary site in the minor salivary gland group included 137 (44%) oral cavity, 38 (12%) pharynx, 3 (0.9%) nasal cavity, and 2 (0.6%) trachea and larynx. The major salivary gland group included 118 (38%) parotid, 8 (3%) submandibular, and 2 (0.6%) sublingual. With a median follow-up of 73 months, 5-year overall survival and disease-specific survival were 84% and 91%, respectively. Patients with tumors located in the hard palate and retromolar trigone had the best survival, while patients with tumors located in the paranasal sinuses and submandibular gland had the poorest survival. After controlling for tumor grade and stage, MEC primary site was not predictive of survival or recurrence. On multivariate analysis, worse DSS was associated with stage III-IV tumors (HR: 7,11; 95% CI: 1.19-26.43; p = 0.0034) and high-grade tumors (HR: 19.12; 95% CI: 2.26-162.77; p = 0.0068).

Conclusions: While high grade and advanced overall stage were found to be independent predictors of worse survival, primary tumor site was not predictive of poor outcome.

Citing Articles

Unusual Presentation of a Parotid Gland Malignancy: A Case Report.

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Predominantly oncocytic mucoepidermoid carcinoma of palate: A case report.

Sarode G, Sarode S, Yuwanati M, Vaidya K J Oral Maxillofac Pathol. 2024; 28(1):134-137.

PMID: 38800424 PMC: 11126252. DOI: 10.4103/jomfp.jomfp_332_23.

Re-evaluating a historic cohort of sinonasal and skull base mucoepidermoid carcinoma: an institutional experience.

Hu C, Lin L, Ye M, Liu Y, Huang Q, Yuan C Diagn Pathol. 2024; 19(1):46.

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Critical Appraisal of Histologic Grading for Mucoepidermoid Carcinoma of Salivary Gland: Is an Objective Prognostic 2-tiered Grading System Possible?.

Xu B, Alzumaili B, Furlan K, Martinez G, Cohen M, Ganly I Am J Surg Pathol. 2023; 47(11):1219-1229.

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A Case of Mucoepidermoid Carcinoma of the Larynx.

Skliris J, Marini K, Poutoglidis A, Matzarakis I, Karamitsou P Cureus. 2023; 15(1):e34455.

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