Boron-containing Nucleosides As Tools for Boron-neutron Capture Therapy

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2021 Nov 12

PMID 34765286

Citations 8

Authors

Dmitry O Zharkov

Anna V Yudkina

Tim Riesebeck

Polina S Loshchenova

Evgeny A Mostovich

Grigory L Dianov

Affiliations

Soon will be listed here.

Abstract

Despite the significant progress in cancer cure, the development of new approaches to cancer therapy is still of great importance since many deadly tumors remain untreatable. Boron neutron capture therapy (BNCT), proposed more than eighty years ago, is still considered a potentially advantageous approach. Irradiation of cells containing B isotopes with epithermal neutrons and the consequent decay of boron nuclei releases particles that deposit high energy along a very short path, inflicting heavy damage on the target cells but sparing the neighbouring tissue. Delivery and preferential accumulation of boron in cancer cells are the major obstacles that slow down the clinical use of BNCT. Since DNA damage caused by irradiation is the major reason for cell death, the incorporation of boron-containing nucleotides into the DNA of cancer cells may significantly increase the efficacy of BNCT. In this review, we discuss the current state of knowledge in the synthesis of boron-containing nucleosides and their application for BNCT with a special focus on their possible incorporation into genomic DNA.

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