Obesity Phenotypes and Their Relationships with Atrial Fibrillation

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2021 Nov 11

PMID 34760366

Citations 2

Authors

Szu-Ying Tsai

Hsin-Hao Chen

Hsin-Yin Hsu

Ming-Chieh Tsai

Le-Yin Hsu

Lee-Ching Hwang

Kuo-Liong Chien

Chien-Ju Lin

Tzu-Lin Yeh

Affiliations

Soon will be listed here.

Abstract

Background: This study assessed the associations of metabolic obesity phenotypes with the risk of atrial fibrillation (Afib).

Methods: This prospective cohort study categorized Taiwanese adults according to their body mass index (BMI) and metabolic health status at baseline. We assigned the participants to the underweight (BMI < 18.5 kg/m), normal weight (BMI = 18.5-23.9 kg/m), and overweight/obesity groups (BMI ≥ 24 kg/m). Metabolically healthy was defined as absence of hypertension, diabetes, and hyperlipidemia and the presence of healthy metabolic profiles.

Results: In total, 5,742 adults were included. During a median follow-up of 13.7 years, 148 patients developed Afib. Compared to the metabolically healthy normal weight group, the risk of Afib was significantly higher than those in the metabolically unhealthy overweight/obesity (hazard ratio = 2.20, 95% confidence interval [1.12-4.33]) and metabolically unhealthy normal weight groups (HR = 2.64, 95% CI [1.34-5.17]). Additionally, the point estimate suggested a 1.97-fold greater risk among the metabolically healthy overweight/obesity group, although this difference was not significant given the wide confidence interval (HR = 1.97, 95% CI [0.80-4.86]).

Conclusion: Our results demonstrated the relationships of metabolic health and weight regarding the risk of Afib in Taiwanese adults. The Afib risk among metabolic and obesity phenotypes is associated with a metabolically unhealthy status. A trend toward a higher Afib risk with obesity among metabolically healthy subjects was observed. However, the result was not robust and it still suggested further study.

Citing Articles

Obesity phenotypes and cardiovascular risk: From pathophysiology to clinical management.

Preda A, Carbone F, Tirandi A, Montecucco F, Liberale L Rev Endocr Metab Disord. 2023; 24(5):901-919.

PMID: 37358728 PMC: 10492705. DOI: 10.1007/s11154-023-09813-5.

Association between metabolically healthy obesity and risk of atrial fibrillation: taking physical activity into consideration.

Wang R, Olier I, Ortega-Martorell S, Liu Y, Ye Z, Lip G Cardiovasc Diabetol. 2022; 21(1):208.

PMID: 36229801 PMC: 9563485. DOI: 10.1186/s12933-022-01644-z.

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