Crosstalk Between the Renin-angiotensin, Complement and Kallikrein-kinin Systems in Inflammation

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2021 Nov 11

PMID 34759348

Citations 63

Authors

Zivile Bekassy

Ingrid Lopatko Fagerstrom

Michael Bader

Diana Karpman

Affiliations

Soon will be listed here.

Abstract

During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin-angiotensin system, the complement system, and the closely linked kallikrein-kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation. Specific attention is given to the role of these systems in systemic inflammation in the vasculature and tissues during hereditary angioedema, cardiovascular and renal glomerular disease, vasculitides and COVID-19. Moreover, we discuss the therapeutic implications of these complex interactions, given that modulation of one system may affect the other systems, with beneficial or deleterious consequences.

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