Ubiquitin-specific Peptidase 37: an Important Cog in the Oncogenic Machinery of Cancerous Cells

Overview

Journal J Exp Clin Cancer Res

Publisher Biomed Central

Specialty Oncology

Date 2021 Nov 11

PMID 34758854

Citations 8

Authors

Ravi Chauhan

Ajaz A Bhat

Tariq Masoodi

Puneet Bagga

Ravinder Reddy

Ashna Gupta

Zahoor Ahmad Sheikh

Muzafar A Macha

Mohammad Haris

Mayank Singh

Affiliations

Soon will be listed here.

Abstract

Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ubiquitination process may lead to tumorigenesis. Ubiquitin-specific peptidases are attractive therapeutic targets in different cancers and are being evaluated for clinical development. Ubiquitin-specific peptidase 37 (USP37) is one of the least studied members of the USP family. USP37 controls numerous aspects of oncogenesis, including stabilizing many different oncoproteins. Recent work highlights the role of USP37 in stimulating the epithelial-mesenchymal transition and metastasis in lung and breast cancer by stabilizing SNAI1 and stimulating the sonic hedgehog pathway, respectively. Several aspects of USP37 biology in cancer cells are yet unclear and are an active area of research. This review emphasizes the importance of USP37 in cancer and how identifying its molecular targets and signalling networks in various cancer types can help advance cancer therapeutics.

Citing Articles

USP37 promotes diffuse large B-cell lymphoma progression by deubiquitinating and stabilizing c-myc.

Li Y, Wang W, Sun L, Huang J, Ma X, Li S J Mol Histol. 2024; 56(1):54.

PMID: 39722070 DOI: 10.1007/s10735-024-10323-0.

Deubiquitinase USP37 enhances the anti-HIV-2/SIV ability of the host restriction factor SAMHD1.

Cui W, Wang H, Gao Y, Zhang X, Xin J, Li Z J Virol. 2024; 99(1):e0185824.

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USP37 prevents premature disassembly of stressed replisomes by TRAIP.

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DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability.

Foster B, Wang Z, Schmidt C Biochem J. 2024; 481(7):515-545.

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Ubiquitin specific peptidase (USP37) mediated effects in microscaffold-encapsulated cells: a comprehensive study on growth, proliferation and EMT.

De S, Chauhan R, Singh M, Singh N RSC Adv. 2024; 14(8):5461-5471.

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