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Schizophrenic Symptoms Improve with Apomorphine

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Journal Science
Specialty Science
Date 1978 May 5
PMID 347574
Citations 33
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Abstract

Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.

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