Toward an Understanding of the Folding of Ribonuclease A

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1987 Aug 1

PMID 3475701

Citations 8

Authors

H A Scheraga

Y Konishi

D M Rothwarf

P W Mui

Affiliations

Soon will be listed here.

Abstract

A mechanism was proposed several years ago for the regeneration of native ribonuclease A (EC 3.1.27.5) from the fully reduced form by a mixture of oxidized and reduced glutathiones. Several folding pathways, depending on the solution conditions, were deduced. It is shown here that recent criticisms of those results are due to a misinterpretation of the analysis of our data. A more detailed description of our method of analysis of our previous kinetic and energetic data is presented in order to clarify possible misconceptions.

Citing Articles

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Definition of amide protection factors for early kinetic intermediates in protein folding.

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