Targeting PINK1 Using Natural Products for the Treatment of Human Diseases

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2021 Nov 9

PMID 34751247

Citations 7

Authors

Yan-Qin Li

Fan Zhang

Li-Ping Yu

Jian-Kang Mu

Ya-Qin Yang

Jie Yu

Xing-Xin Yang

Affiliations

Soon will be listed here.

Abstract

, also known as , is a -induced putative kinase 1 that is encoded by nuclear genes. PINK1 is ubiquitously expressed and regulates mitochondrial function and mitophagy in a range of cell types. The dysregulation of PINK1 is associated with the pathogenesis and development of mitochondrial-associated disorders. Many natural products could regulate PINK1 to relieve PINK1-associated diseases. Here, we review the structure and function of PINK1, its relationship to human diseases, and the regulation of natural products to PINK1. We further highlight that the discovery of natural PINK1 regulators represents an attractive strategy for the treatment of PINK1-related diseases, including liver and heart diseases, cancer, and Parkinson's disease. Moreover, investigating PINK1 regulation of natural products can enhance the in-depth comprehension of the mechanism of action of natural products.

Citing Articles

Gut microbiota in insulin resistance: a bibliometric analysis.

Tian W, Liu L, Wang R, Quan Y, Tang B, Yu D J Diabetes Metab Disord. 2024; 23(1):173-188.

PMID: 38932838 PMC: 11196565. DOI: 10.1007/s40200-023-01342-x.

Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease.

Lopez-Valverde N, Lopez-Valverde A, Macedo de Sousa B, Blanco Rueda J Front Bioeng Biotechnol. 2024; 11:1309851.

PMID: 38344076 PMC: 10857001. DOI: 10.3389/fbioe.2023.1309851.

Autophagy/Mitophagy in Airway Diseases: Impact of Oxidative Stress on Epithelial Cells.

Albano G, Montalbano A, Gagliardo R, Profita M Biomolecules. 2023; 13(8).

PMID: 37627282 PMC: 10452925. DOI: 10.3390/biom13081217.

Modulating Effects of Cancer-Derived Exosomal miRNAs and Exosomal Processing by Natural Products.

Chuang Y, Tang J, Shiau J, Yen C, Chang F, Yang K Cancers (Basel). 2023; 15(1).

PMID: 36612314 PMC: 9818271. DOI: 10.3390/cancers15010318.

Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2.

Byrne D, Shrestha S, Daly L, Marensi V, Ramakrishnan K, Eyers C Biochem J. 2022; 480(2):141-160.

PMID: 36520605 PMC: 9988210. DOI: 10.1042/BCJ20220474.

References

Pacher P, Hajnoczky G . Propagation of the apoptotic signal by mitochondrial waves. EMBO J. 2001; 20(15):4107-21. PMC: 149166. DOI: 10.1093/emboj/20.15.4107. View

Bi W, Jia J, Pang R, Nie C, Han J, Ding Z . Thyroid hormone postconditioning protects hearts from ischemia/reperfusion through reinforcing mitophagy. Biomed Pharmacother. 2019; 118:109220. DOI: 10.1016/j.biopha.2019.109220. View

Hong J, Lee S . Heme oxygenase-1 protects liver against ischemia/reperfusion injury via phosphoglycerate mutase family member 5-mediated mitochondrial quality control. Life Sci. 2018; 200:94-104. DOI: 10.1016/j.lfs.2018.03.017. View

MacKeigan J, Murphy L, Blenis J . Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol. 2005; 7(6):591-600. DOI: 10.1038/ncb1258. View

Hou J, Yun Y, Xue J, Jeon B, Kim S . Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2. Phytother Res. 2020; 34(7):1659-1669. DOI: 10.1002/ptr.6636. View

Li R, Chen J . Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy. Oxid Med Cell Longev. 2019; 2019:9341018. PMC: 6754964. DOI: 10.1155/2019/9341018. View

Moyzis A, Gustafsson A . Multiple recycling routes: Canonical vs. non-canonical mitophagy in the heart. Biochim Biophys Acta Mol Basis Dis. 2018; 1865(4):797-809. DOI: 10.1016/j.bbadis.2018.09.034. View

Zhang S, Yu Z, Xia J, Zhang X, Liu K, Sik A . Anti-Parkinson's disease activity of phenolic acids from Eucommia ulmoides Oliver leaf extracts and their autophagy activation mechanism. Food Funct. 2020; 11(2):1425-1440. DOI: 10.1039/c9fo02288k. View

Friedman S, Neuschwander-Tetri B, Rinella M, Sanyal A . Mechanisms of NAFLD development and therapeutic strategies. Nat Med. 2018; 24(7):908-922. PMC: 6553468. DOI: 10.1038/s41591-018-0104-9. View

10.

Verma M, Zhu J, Wang K, Chu C . Chronic treatment with the complex I inhibitor MPP depletes endogenous PTEN-induced kinase 1 (PINK1) via up-regulation of Bcl-2-associated athanogene 6 (BAG6). J Biol Chem. 2020; 295(23):7865-7876. PMC: 7278356. DOI: 10.1074/jbc.RA119.010474. View

11.

Zheng J, Chen L, Lu T, Zhang Y, Sui X, Li Y . MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation. Cell Death Dis. 2020; 11(4):256. PMC: 7171190. DOI: 10.1038/s41419-020-2424-1. View

12.

Hou Y, Tang Y, Wang X, Ai X, Wang H, Li X . ameliorates exhaustive exercise-induced fatigue in mice by suppressing mitophagy in skeletal muscle. Exp Ther Med. 2020; 20(4):3161-3173. PMC: 7444336. DOI: 10.3892/etm.2020.9072. View

13.

Okatsu K, Sato Y, Yamano K, Matsuda N, Negishi L, Takahashi A . Structural insights into ubiquitin phosphorylation by PINK1. Sci Rep. 2018; 8(1):10382. PMC: 6039469. DOI: 10.1038/s41598-018-28656-8. View

14.

Manning G, Whyte D, Martinez R, Hunter T, Sudarsanam S . The protein kinase complement of the human genome. Science. 2002; 298(5600):1912-34. DOI: 10.1126/science.1075762. View

15.

Liu K, Lee J, Kim J, Wang L, Tian Y, Chan S . Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells. Mol Cell. 2017; 68(2):281-292.e5. PMC: 5687282. DOI: 10.1016/j.molcel.2017.09.022. View

16.

Liu X, Wang W, Song G, Wei X, Zeng Y, Han P . Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network. PLoS One. 2017; 12(8):e0182558. PMC: 5540580. DOI: 10.1371/journal.pone.0182558. View

17.

Xiang Q, Wu M, Zhang L, Fu W, Yang J, Zhang B . Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury. Front Pharmacol. 2020; 11:452. PMC: 7175665. DOI: 10.3389/fphar.2020.00452. View

18.

Zhi Y, Jin Y, Pan L, Zhang A, Liu F . Schisandrin A ameliorates MPTP-induced Parkinson's disease in a mouse model via regulation of brain autophagy. Arch Pharm Res. 2019; 42(11):1012-1020. DOI: 10.1007/s12272-019-01186-1. View

19.

Kang J, Choi H, Lee S . Resolvin D1 attenuates liver ischaemia/reperfusion injury through modulating thioredoxin 2-mediated mitochondrial quality control. Br J Pharmacol. 2018; 175(12):2441-2453. PMC: 5980610. DOI: 10.1111/bph.14212. View

20.

Wei R, Cao J, Yao S . Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways. Cell Stress Chaperones. 2018; 23(6):1295-1309. PMC: 6237690. DOI: 10.1007/s12192-018-0937-7. View