Pancreatic Ductal Adenocarcinoma: Preclinical and Models

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Nov 8

PMID 34746135

Citations 16

Authors

Beate Gundel

Xinyuan Liu

Matthias Lohr

Rainer Heuchel

Affiliations

Soon will be listed here.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most overlooked cancers despite its dismal median survival time of 6 months. The biggest challenges in improving patient survival are late diagnosis due to lack of diagnostic markers, and limited treatment options due to almost complete therapy resistance. The past decades of research identified the dense stroma and the complex interplay/crosstalk between the cancer- and the different stromal cells as the main culprits for the slow progress in improving patient outcome. For better simulation of this complex tumor microenvironment the models used in PDAC research likewise need to become more diverse. Depending on the focus of the investigation, several and models for PDAC have been established in the past years. Particularly, 3D cell culture such as spheroids and organoids have become more frequently used. This review aims to examine current PDAC models, their inherent limitations, and their successful implementations in research.

Citing Articles

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