Stem Cell-Based Therapies in Hearing Loss

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Nov 8

PMID 34746126

Citations 13

Authors

Zuhong He

Yanyan Ding

Yurong Mu

Xiaoxiang Xu

Weijia Kong

Renjie Chai

Xiong Chen

Affiliations

Soon will be listed here.

Abstract

In recent years, neural stem cell transplantation has received widespread attention as a new treatment method for supplementing specific cells damaged by disease, such as neurodegenerative diseases. A number of studies have proved that the transplantation of neural stem cells in multiple organs has an important therapeutic effect on activation and regeneration of cells, and restore damaged neurons. This article describes the methods for inducing the differentiation of endogenous and exogenous stem cells, the implantation operation and regulation of exogenous stem cells after implanted into the inner ear, and it elaborates the relevant signal pathways of stem cells in the inner ear, as well as the clinical application of various new materials. At present, stem cell therapy still has limitations, but the role of this technology in the treatment of hearing diseases has been widely recognized. With the development of related research, stem cell therapy will play a greater role in the treatment of diseases related to the inner ear.

Citing Articles

Current and emerging approaches to cochlear immunosuppression with translation to human inner ear stem cell therapy: A systematic review.

Creber N, Muzaffar J, Gowrishankar S, Borsetto D, Phillips V, Smith M PLoS One. 2025; 20(2):e0318165.

PMID: 39946404 PMC: 11825040. DOI: 10.1371/journal.pone.0318165.

Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation.

Li Z, Gao Y, Chen X, Xu L, Li Z, Chai R Adv Sci (Weinh). 2024; 12(5):e2410919.

PMID: 39716878 PMC: 11791950. DOI: 10.1002/advs.202410919.

Chromosome-level genome and population genomics of the intermediate horseshoe bat ( reveal the molecular basis of virus tolerance in and echolocation call frequency variation.

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PMID: 39257377 PMC: 11491789. DOI: 10.24272/j.issn.2095-8137.2024.027.

Photobiomodulation Can Enhance Stem Cell Viability in Cochlea with Auditory Neuropathy but Does Not Restore Hearing.

Chang S, Kim E, Carpena N, Lee J, Kim D, Lee M Stem Cells Int. 2023; 2023:6845571.

PMID: 38020205 PMC: 10665102. DOI: 10.1155/2023/6845571.

Stem cells as potential therapeutics for hearing loss.

Fang Q, Wei Y, Zhang Y, Cao W, Yan L, Kong M Front Neurosci. 2023; 17:1259889.

PMID: 37746148 PMC: 10512725. DOI: 10.3389/fnins.2023.1259889.

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