Design and Applications of Tumor Microenvironment-Responsive Nanogels As Drug Carriers

Overview

Journal Front Bioeng Biotechnol

Date 2021 Nov 8

PMID 34746113

Citations 4

Authors

Xinjing Du

Yuting Gao

Qi Kang

Jinfeng Xing

Affiliations

Soon will be listed here.

Abstract

In recent years, the exploration of tumor microenvironment has provided a new approach for tumor treatment. More and more researches are devoted to designing tumor microenvironment-responsive nanogels loaded with therapeutic drugs. Compared with other drug carriers, nanogel has shown great potential in improving the effect of chemotherapy, which is attributed to its stable size, superior hydrophilicity, excellent biocompatibility, and responsiveness to specific environment. This review primarily summarizes the common preparation techniques of nanogels (such as free radical polymerization, covalent cross-linking, and physical self-assembly) and loading ways of drug in nanogels (including physical encapsulation and chemical coupling) as well as the controlled drug release behaviors. Furthermore, the difficulties and prospects of nanogels as drug carriers are also briefly described.

Citing Articles

Biopolymeric Nanogel as a Drug Delivery System for Doxorubicin-Improved Drug Stability and Enhanced Antineoplastic Activity in Skin Cancer Cells.

Radeva L, Zaharieva M, Spassova I, Kovacheva D, Tibi I, Najdenski H Pharmaceuticals (Basel). 2024; 17(2).

PMID: 38399401 PMC: 10891966. DOI: 10.3390/ph17020186.

Exploring novel strategies to improve anti-tumour efficiency: The potential for targeting reactive oxygen species.

Chasara R, Ajayi T, Leshilo D, Poka M, Witika B Heliyon. 2023; 9(9):e19896.

PMID: 37809420 PMC: 10559285. DOI: 10.1016/j.heliyon.2023.e19896.

Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents.

Kubeil M, Suzuki Y, Casulli M, Kamal R, Hashimoto T, Bachmann M Adv Healthc Mater. 2023; 13(1):e2301404.

PMID: 37717209 PMC: 11468994. DOI: 10.1002/adhm.202301404.

CuAAC ensembled 1,2,3-triazole linked nanogels for targeted drug delivery: a review.

Singh G, Majeed A, Singh R, George N, Singh G, Gupta S RSC Adv. 2023; 13(5):2912-2936.

PMID: 36756399 PMC: 9847229. DOI: 10.1039/d2ra05592a.

References

Shah S, Rangaraj N, Laxmikeshav K, Sampathi S . "Nanogels as drug carriers - Introduction, chemical aspects, release mechanisms and potential applications". Int J Pharm. 2020; 581:119268. DOI: 10.1016/j.ijpharm.2020.119268. View

Wang Y, Zheng J, Tian Y, Yang W . Acid degradable poly(vinylcaprolactam)-based nanogels with ketal linkages for drug delivery. J Mater Chem B. 2020; 3(28):5824-5832. DOI: 10.1039/c5tb00703h. View

Wu C, Hu W, Wei Q, Qiao L, Gao Y, Lv Y . Controllable Growth of Core-Shell Nanogels via Esterase-Induced Self-Assembly of Peptides for Drug Delivery. J Biomed Nanotechnol. 2019; 14(2):354-361. DOI: 10.1166/jbn.2018.2492. View

Perez-Alvarez L, Laza J, Alvarez-Bautista A . Covalently and Ionically Crosslinked Chitosan Nanogels for Drug Delivery. Curr Pharm Des. 2016; 22(22):3380-98. DOI: 10.2174/1381612822666160216152008. View

Ahmed E . Hydrogel: Preparation, characterization, and applications: A review. J Adv Res. 2015; 6(2):105-21. PMC: 4348459. DOI: 10.1016/j.jare.2013.07.006. View

Pei M, Jia X, Zhao X, Li J, Liu P . Alginate-based cancer-associated, stimuli-driven and turn-on theranostic prodrug nanogel for cancer detection and treatment. Carbohydr Polym. 2018; 183:131-139. DOI: 10.1016/j.carbpol.2017.12.013. View

Rhee M, Valencia P, Rodriguez M, Langer R, Farokhzad O, Karnik R . Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels. Adv Mater. 2011; 23(12):H79-83. PMC: 3123733. DOI: 10.1002/adma.201004333. View

Siegwart D, Srinivasan A, Bencherif S, Karunanidhi A, Oh J, Vaidya S . Cellular uptake of functional nanogels prepared by inverse miniemulsion ATRP with encapsulated proteins, carbohydrates, and gold nanoparticles. Biomacromolecules. 2009; 10(8):2300-9. PMC: 5305297. DOI: 10.1021/bm9004904. View

Zhao G, Long L, Zhang L, Peng M, Cui T, Wen X . Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery. Sci Rep. 2017; 7(1):3383. PMC: 5469818. DOI: 10.1038/s41598-017-03111-2. View

10.

Lanfear J, FLEMING J, Wu L, Webster G, Harrison P . The selenium metabolite selenodiglutathione induces p53 and apoptosis: relevance to the chemopreventive effects of selenium?. Carcinogenesis. 1994; 15(7):1387-92. DOI: 10.1093/carcin/15.7.1387. View

11.

Li Z, Huang J, Wu J . pH-Sensitive nanogels for drug delivery in cancer therapy. Biomater Sci. 2020; 9(3):574-589. DOI: 10.1039/d0bm01729a. View

12.

Yoon H, Koo H, Choi K, Lee S, Kim K, Kwon I . Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy. Biomaterials. 2012; 33(15):3980-9. DOI: 10.1016/j.biomaterials.2012.02.016. View

13.

Xiao K, Li Y, Luo J, Lee J, Xiao W, Gonik A . The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles. Biomaterials. 2011; 32(13):3435-46. PMC: 3055170. DOI: 10.1016/j.biomaterials.2011.01.021. View

14.

Le Quemener F, Subervie D, Morlet-Savary F, Lalevee J, Lansalot M, Bourgeat-Lami E . Visible-Light Emulsion Photopolymerization of Styrene. Angew Chem Int Ed Engl. 2017; 57(4):957-961. DOI: 10.1002/anie.201710488. View

15.

Qu Y, Chu B, Wei X, Lei M, Hu D, Zha R . Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for "on-demand" drug delivery. J Control Release. 2019; 296:93-106. DOI: 10.1016/j.jconrel.2019.01.016. View

16.

Maiti D, Chao Y, Dong Z, Yi X, He J, Liu Z . Development of a thermosensitive protein conjugated nanogel for enhanced radio-chemotherapy of cancer. Nanoscale. 2018; 10(29):13976-13985. DOI: 10.1039/c8nr03986k. View

17.

Azadi A, Hamidi M, Khoshayand M, Amini M, Rouini M . Preparation and optimization of surface-treated methotrexate-loaded nanogels intended for brain delivery. Carbohydr Polym. 2014; 90(1):462-71. DOI: 10.1016/j.carbpol.2012.05.066. View

18.

Yu Y, Cheng Y, Tong J, Zhang L, Wei Y, Tian M . Recent advances in thermo-sensitive hydrogels for drug delivery. J Mater Chem B. 2021; 9(13):2979-2992. DOI: 10.1039/d0tb02877k. View

19.

Clegg J, Ludolph C, Peppas N . QCM-D assay for quantifying the swelling, biodegradation, and protein adsorption of intelligent nanogels. J Appl Polym Sci. 2021; 137(25). PMC: 8562820. DOI: 10.1002/app.48655. View

20.

Tai W, Mo R, Lu Y, Jiang T, Gu Z . Folding graft copolymer with pendant drug segments for co-delivery of anticancer drugs. Biomaterials. 2014; 35(25):7194-203. PMC: 4107449. DOI: 10.1016/j.biomaterials.2014.05.004. View