LncRNA PPM1A-AS Regulate Tumor Development Through Multiple Signal Pathways in T-Cell Acute Lymphoblastic Leukemia

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Nov 8

PMID 34746000

Citations 5

Authors

Guoli Li

Xinyue Lei

Yingchi Zhang

Zhe Liu

Kegan Zhu

Affiliations

Soon will be listed here.

Abstract

ALL (Acute lymphoblastic leukemia) is the most common pediatric malignancy and T-ALL (T-cell acute lymphoblastic leukemia) comprises about 15% cases. Compared with B-ALL (B-cell acute lymphoblastic leukemia), the prognosis of T-ALL is poorer, the chemotherapy is easier to fail and the relapse rate is higher. Previous studies mainly focused in Notch1-related long non-coding RNAs (lncRNAs) in T-ALL. Here, we intend to investigate lncRNAs involved in T-ALL covering different subtypes. The lncRNA PPM1A-AS was screened out for its significant up-regulation in 10 T-ALL samples of different subtypes than healthy human thymus extracts. Besides, the PPM1A-AS expression levels in 3 T-ALL cell lines are markedly higher than that in CD45 T cells of healthy human. We further demonstrate that PPM1A-AS can promote cell proliferation and inhibit cell apoptosis and can influence T-ALL growth . Finally, we verified that PPM1A-AS can regulate core proteins, Notch4, STAT3 and Akt, of 3 important signaling pathways related to T-ALL. These results confirm that lncRNA PPM1A-AS can act as an oncogene in T-ALL and maybe a potential clinical target of patients resistant to current chemotherapy or relapsed cases.

Citing Articles

Long Non-Coding RNA Signatures in Lymphopoiesis and Lymphoid Malignancies.

Baghdadi H, Heidari R, Zavvar M, Ahmadi N, Khomartash M, Vahidi M Noncoding RNA. 2023; 9(4).

PMID: 37624036 PMC: 10458434. DOI: 10.3390/ncrna9040044.

Long non-coding RNAs regulate treatment outcome in leukemia: What have we learnt recently?.

Shi H, Gao L, Zhang W, Jiang M Cancer Med. 2023; 12(13):13966-13977.

PMID: 37148556 PMC: 10358217. DOI: 10.1002/cam4.6027.

Notch Partners in the Long Journey of T-ALL Pathogenesis.

Toribio M, Gonzalez-Garcia S Int J Mol Sci. 2023; 24(2).

PMID: 36674902 PMC: 9866461. DOI: 10.3390/ijms24021383.

Proteomic profiling of plasma exosomes from patients with B-cell acute lymphoblastic leukemia.

Zhu S, Xing C, Li R, Cheng Z, Deng M, Luo Y Sci Rep. 2022; 12(1):11975.

PMID: 35831551 PMC: 9279438. DOI: 10.1038/s41598-022-16282-4.

Linear and Circular Long Non-Coding RNAs in Acute Lymphoblastic Leukemia: From Pathogenesis to Classification and Treatment.

Maimaitiyiming Y, Ye L, Yang T, Yu W, Naranmandura H Int J Mol Sci. 2022; 23(8).

PMID: 35457264 PMC: 9033105. DOI: 10.3390/ijms23084442.

References

Porcher C, Chagraoui H, Kristiansen M . SCL/TAL1: a multifaceted regulator from blood development to disease. Blood. 2017; 129(15):2051-2060. DOI: 10.1182/blood-2016-12-754051. View

Verboom K, Van Loocke W, Volders P, Decaesteker B, Avila Cobos F, Bornschein S . A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing. Haematologica. 2018; 103(12):e585-e589. PMC: 6269303. DOI: 10.3324/haematol.2018.190587. View

Vadillo E, Dorantes-Acosta E, Pelayo R, Schnoor M . T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies. Blood Rev. 2017; 32(1):36-51. DOI: 10.1016/j.blre.2017.08.006. View

Brender C, Nielsen M, Kaltoft K, Mikkelsen G, Zhang Q, Wasik M . STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma. Blood. 2001; 97(4):1056-62. DOI: 10.1182/blood.v97.4.1056. View

Somervaille T, Linch D, Khwaja A . Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax. Blood. 2001; 98(5):1374-81. DOI: 10.1182/blood.v98.5.1374. View

Girardi T, Vicente C, Cools J, De Keersmaecker K . The genetics and molecular biology of T-ALL. Blood. 2017; 129(9):1113-1123. PMC: 5363819. DOI: 10.1182/blood-2016-10-706465. View

Wang Y, Wu P, Lin R, Rong L, Xue Y, Fang Y . LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia. Sci Rep. 2015; 5:13749. PMC: 4557127. DOI: 10.1038/srep13749. View

Luo K . Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways. Cold Spring Harb Perspect Biol. 2016; 9(1). PMC: 5204325. DOI: 10.1101/cshperspect.a022137. View

Karrman K, Johansson B . Pediatric T-cell acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2016; 56(2):89-116. DOI: 10.1002/gcc.22416. View

10.

Kopp F, Mendell J . Functional Classification and Experimental Dissection of Long Noncoding RNAs. Cell. 2018; 172(3):393-407. PMC: 5978744. DOI: 10.1016/j.cell.2018.01.011. View

11.

Delgado-Martin C, Meyer L, Huang B, Shimano K, Zinter M, Nguyen J . JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. Leukemia. 2017; 31(12):2568-2576. PMC: 5729333. DOI: 10.1038/leu.2017.136. View

12.

Costa M, Wu X, Cuervo H, Srinivasan R, Bechis S, Cheang E . Notch4 is required for tumor onset and perfusion. Vasc Cell. 2013; 5(1):7. PMC: 3644271. DOI: 10.1186/2045-824X-5-7. View

13.

Belver L, Ferrando A . The genetics and mechanisms of T cell acute lymphoblastic leukaemia. Nat Rev Cancer. 2016; 16(8):494-507. DOI: 10.1038/nrc.2016.63. View

14.

Cook L, Fuji S, Hermine O, Bazarbachi A, Ramos J, Ratner L . Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. J Clin Oncol. 2019; 37(8):677-687. PMC: 6494249. DOI: 10.1200/JCO.18.00501. View

15.

Lobry C, Oh P, Mansour M, Look A, Aifantis I . Notch signaling: switching an oncogene to a tumor suppressor. Blood. 2014; 123(16):2451-9. PMC: 3990910. DOI: 10.1182/blood-2013-08-355818. View

16.

Gutierrez A, Look A . NOTCH and PI3K-AKT pathways intertwined. Cancer Cell. 2007; 12(5):411-3. DOI: 10.1016/j.ccr.2007.10.027. View

17.

Bhan A, Soleimani M, Mandal S . Long Noncoding RNA and Cancer: A New Paradigm. Cancer Res. 2017; 77(15):3965-3981. PMC: 8330958. DOI: 10.1158/0008-5472.CAN-16-2634. View

18.

Trimarchi T, Bilal E, Ntziachristos P, Fabbri G, Dalla-Favera R, Tsirigos A . Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia. Cell. 2014; 158(3):593-606. PMC: 4131209. DOI: 10.1016/j.cell.2014.05.049. View

19.

Ngoc P, Tan S, Tan T, Chan M, Li Z, Yeoh A . Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia. Leukemia. 2018; 32(10):2138-2151. PMC: 8197659. DOI: 10.1038/s41375-018-0110-4. View

20.

Sanchez-Martin M, Ferrando A . The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia. Blood. 2017; 129(9):1124-1133. DOI: 10.1182/blood-2016-09-692582. View