Correlation of Serum Decoy Receptor 3 and Interleukin-6 with Severity of Coronary Artery Diseases in Male Acute Myocardial Infarction Patients

Overview

Journal Acta Biomed

Specialty General Medicine

Date 2021 Nov 5

PMID 34738600

Citations 4

Authors

Hossein Doustkami

Leli Avesta

Behzad Babapour

Mohammad Hossein Boskabady

Ali Nikoukhesal

Mohammad Reza Aslani

Affiliations

Soon will be listed here.

Abstract

Background: Decoy receptor 3 (DcR3), is a soluble receptor which is thought to have immune modulator or pro-inflammatory effects. Various risk factors have been suggested for the incidence of cardiovascular diseases (CADs) such as an increase in inflammatory factors. The purpose of the present study was to investigate the correlation of DcR3 with anthropometric, angiographic, echocardiographic, and biochemical parameters in patients with acute myocardial infarction.

Methods And Materials: A total of 90 patients who were candidates for angiography were included in the study and were divided into three groups: 30 patients with acute myocardial infarction (AMI), 30 patients with stable angina pectoris (SAP), and 30 subjects as control group with a history of chest pain but normal angiography. Anthropometric, angiographic, echocardiographic, and biochemical parameters were measured in all subjects.

Results: Serum DcR3 and interleukin (IL)-6 levels were significantly increased in patients with AMI compared with SAP and control groups (P < 0.05 to P < 0.001). In addition, there was a positive association between serum level of DcR3 and epicardial fat thickness (EFT), Gensini score, creatine kinase (CK)-MB, IL-6, and white blood cell (WBC) count in CAD patients. The results of multivariate linear regression analysis revealed that WBC count and IL-6 levels were independently associated with serum DcR3 levels.

Conclusion: The current study showed an association of DcR3 and IL-6, WBC count, EFT, CK-MB, and Gensini score for the first time in male AMI patients. Increased DcR3 levels in patients with AMI may be involved in the process of atherosclerosis.

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References

Lin W, Hsieh S . Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer. Biochem Pharmacol. 2011; 81(7):838-47. DOI: 10.1016/j.bcp.2011.01.011. View

Okazaki S, Sakaguchi M, Miwa K, Furukado S, Yamagami H, Yagita Y . Association of interleukin-6 with the progression of carotid atherosclerosis: a 9-year follow-up study. Stroke. 2014; 45(10):2924-9. DOI: 10.1161/STROKEAHA.114.005991. View

Ohashi K, Shibata R, Murohara T, Ouchi N . Role of anti-inflammatory adipokines in obesity-related diseases. Trends Endocrinol Metab. 2014; 25(7):348-55. DOI: 10.1016/j.tem.2014.03.009. View

Kockx M, Herman A . Apoptosis in atherosclerosis: beneficial or detrimental?. Cardiovasc Res. 2000; 45(3):736-46. DOI: 10.1016/s0008-6363(99)00235-7. View

Aslani M, Keyhanmanesh R, Khamaneh A, Saadatlou M, Mesgari Abbasi M, Alipour M . Lung Altered Expression of IL-1β mRNA and Its Signaling Pathway Molecules in Obese-asthmatic Male Wistar Rats. Iran J Allergy Asthma Immunol. 2016; 15(3):183-97. View

Keyhanmanesh R, Alipour M, Ebrahimi H, Aslani M . Effects of Diet-Induced Obesity on Tracheal Responsiveness to Methacholine, Tracheal Visfatin Level, and Lung Histological Changes in Ovalbumin-Sensitized Female Wistar Rats. Inflammation. 2018; 41(3):846-858. DOI: 10.1007/s10753-018-0738-2. View

Sullivan D, Marwick T, Freedman S . A new method of scoring coronary angiograms to reflect extent of coronary atherosclerosis and improve correlation with major risk factors. Am Heart J. 1990; 119(6):1262-7. DOI: 10.1016/s0002-8703(05)80173-5. View

Gao L, Yang B, Zhang H, Ou Q, Lin Y, Zhang M . DcR3, a new biomarker for sepsis, correlates with infection severity and procalcitonin. Oncotarget. 2018; 9(13):10934-10944. PMC: 5834251. DOI: 10.18632/oncotarget.23736. View

Cardinale C, Wei Z, Panossian S, Wang F, Kim C, Mentch F . Targeted resequencing identifies defective variants of decoy receptor 3 in pediatric-onset inflammatory bowel disease. Genes Immun. 2013; 14(7):447-52. DOI: 10.1038/gene.2013.43. View

10.

Yang C, Hsieh S, Ho F, Lin W . Decoy receptor 3 increases monocyte adhesion to endothelial cells via NF-kappa B-dependent up-regulation of intercellular adhesion molecule-1, VCAM-1, and IL-8 expression. J Immunol. 2005; 174(3):1647-56. DOI: 10.4049/jimmunol.174.3.1647. View

11.

Hung S, Hsu T, Lin Y, Tarng D . Decoy receptor 3, a novel inflammatory marker, and mortality in hemodialysis patients. Clin J Am Soc Nephrol. 2012; 7(8):1257-65. PMC: 3408125. DOI: 10.2215/CJN.08410811. View

12.

Xiu Z, Shen H, Tian Y, Xia L, Lu J . Serum and synovial fluid levels of tumor necrosis factor-like ligand 1A and decoy receptor 3 in rheumatoid arthritis. Cytokine. 2015; 72(2):185-9. DOI: 10.1016/j.cyto.2014.12.026. View

13.

Chang Y, Hsu T, Lin H, Chio C, Chiu A, Chen N . Modulation of macrophage differentiation and activation by decoy receptor 3. J Leukoc Biol. 2003; 75(3):486-94. DOI: 10.1189/jlb.0903448. View

14.

Cheng C, Sytwu H, Chang D . Decoy receptor 3 attenuates collagen-induced arthritis by modulating T cell activation and B cell expansion. J Rheumatol. 2011; 38(12):2522-35. DOI: 10.3899/jrheum.110245. View

15.

Baker A, da Silva N, Quinn D, Harte A, Pagano D, Bonser R . Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol. 2006; 5:1. PMC: 1352345. DOI: 10.1186/1475-2840-5-1. View

16.

Mazurek T, Zhang L, Zalewski A, Mannion J, Diehl J, Arafat H . Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003; 108(20):2460-6. DOI: 10.1161/01.CIR.0000099542.57313.C5. View

17.

Chen C, Yang K, Chen M, Chen H, Lin M, Lee Y . Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome. Am J Respir Crit Care Med. 2009; 180(8):751-60. DOI: 10.1164/rccm.200902-0222OC. View

18.

Iacobellis G, Willens H . Echocardiographic epicardial fat: a review of research and clinical applications. J Am Soc Echocardiogr. 2009; 22(12):1311-9. DOI: 10.1016/j.echo.2009.10.013. View

19.

Akhavanakbari G, Babapour B, Alipour M, Keyhanmanesh R, Ahmadi M, Aslani M . Effect of high fat diet on NF-кB microRNA146a negative feedback loop in ovalbumin-sensitized rats. Biofactors. 2018; 45(1):75-84. DOI: 10.1002/biof.1466. View

20.

Nagueh S, Smiseth O, Appleton C, Byrd 3rd B, Dokainish H, Edvardsen T . Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016; 29(4):277-314. DOI: 10.1016/j.echo.2016.01.011. View