» Articles » PMID: 34737791

Molecular Signatures of Human Chronic Atrial Fibrillation in Primary Mitral Regurgitation

Overview
Journal Cardiovasc Ther
Publisher Hindawi
Date 2021 Nov 5
PMID 34737791
Citations 13
Authors
Affiliations
Soon will be listed here.
Abstract

Objectives: Transcriptomics of atrial fibrillation (AFib) in the setting of chronic primary mitral regurgitation (MR) remains to be characterized. We aimed to compare the gene expression profiles of patients with degenerative MR in AFib and sinus rhythm (SR) for a clearer picture of AFib pathophysiology.

Methods: After transcriptomic analysis and bioinformatics ( = 59), differentially expressed genes were defined using 1.5-fold change as the threshold. Additionally, independent datasets from GEO were included as meta-analyses.

Results: QRT-PCR analysis confirmed that AFib persistence was associated with increased expression molecular changes underlying a transition to heart failure (, = 0.002; , = 0.002; , = 0.010), structural remodeling including changes in the extracellular matrix and cellular stress response (, = 0.003; , = 0.028; , = 0.038; , = 0.038), and cellular stress response (, = 0.038). Furthermore, AFib persistence was associated with decreased expression of the targets of structural remodeling (, = 0.021) and electrical remodeling (, = 0.035; , = 0.035) in both left and right atrial samples. The transmission electron microscopic analysis confirmed ultrastructural atrial remodeling and autophagy in human AFib atrial samples.

Conclusions: Atrial cardiomyocyte remodeling in persistent AFib is closely linked to alterations in gene expression profiles compared to SR in patients with primary MR. Study findings may lead to novel therapeutic targets. This trial is registered with ClinicalTrials.gov identifier: NCT00970034.

Citing Articles

Identification of key genes and regulatory networks involved in the Comorbidity of atrial fibrillation and chronic obstructive pulmonary disease.

Xiong S, Liu Q, Zhou S, Xiao Y Heliyon. 2025; 9(11):e22430.

PMID: 39811093 PMC: 11731475. DOI: 10.1016/j.heliyon.2023.e22430.


Exploring the shared biomarkers between cardioembolic stroke and atrial fibrillation by WGCNA and machine learning.

Zhang J, Zhang B, Li T, Li Y, Zhu Q, Wang X Front Cardiovasc Med. 2024; 11:1375768.

PMID: 39267804 PMC: 11390589. DOI: 10.3389/fcvm.2024.1375768.


Atrial cardiomyopathy revisited-evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American....

Goette A, Corradi D, Dobrev D, Aguinaga L, Cabrera J, Chugh S Europace. 2024; 26(9).

PMID: 39077825 PMC: 11431804. DOI: 10.1093/europace/euae204.


Identification of key differentially expressed immune related genes in patients with persistent atrial fibrillation: an integrated bioinformation analysis.

Tao Y, Feng T, Zhou L, Han L BMC Cardiovasc Disord. 2024; 24(1):346.

PMID: 38977948 PMC: 11229288. DOI: 10.1186/s12872-024-04007-6.


Compartmentalization proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation.

Ayagama T, Charles P, Bose S, Boland B, Priestman D, Aston D iScience. 2024; 27(6):109609.

PMID: 38827406 PMC: 11141153. DOI: 10.1016/j.isci.2024.109609.


References
1.
Lamirault G, Gaborit N, le Meur N, Chevalier C, Lande G, Demolombe S . Gene expression profile associated with chronic atrial fibrillation and underlying valvular heart disease in man. J Mol Cell Cardiol. 2005; 40(1):173-84. DOI: 10.1016/j.yjmcc.2005.09.004. View

2.
Wang J, Duncan D, Shi Z, Zhang B . WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013. Nucleic Acids Res. 2013; 41(Web Server issue):W77-83. PMC: 3692109. DOI: 10.1093/nar/gkt439. View

3.
Molina-Navarro M, Rosello-Lleti E, Ortega A, Tarazon E, Otero M, Martinez-Dolz L . Differential gene expression of cardiac ion channels in human dilated cardiomyopathy. PLoS One. 2013; 8(12):e79792. PMC: 3855055. DOI: 10.1371/journal.pone.0079792. View

4.
Wiersma M, Meijering R, Qi X, Zhang D, Liu T, Hoogstra-Berends F . Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation. J Am Heart Assoc. 2017; 6(10). PMC: 5721854. DOI: 10.1161/JAHA.117.006458. View

5.
Roselli C, Chaffin M, Weng L, Aeschbacher S, Ahlberg G, Albert C . Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018; 50(9):1225-1233. PMC: 6136836. DOI: 10.1038/s41588-018-0133-9. View