Comparative Signatures of Selection Analyses Identify Loci Under Positive Selection in the Murrah Buffalo of India

Overview

Journal Front Genet

Date 2021 Nov 5

PMID 34737760

Citations 2

Authors

Shiv K Tyagi

Arnav Mehrotra

Akansha Singh

Amit Kumar

Triveni Dutt

Bishnu P Mishra

Ashwni K Pandey

Affiliations

Soon will be listed here.

Abstract

India is home to a large and diverse buffalo population. The Murrah breed of North India is known for its milk production, and it has been used in breeding programs in several countries. Selection signature analysis yield valuable information about how the natural and artificial selective pressures have shaped the genomic landscape of modern-day livestock species. Genotype information was generated on six buffalo breeds of India, namely, Murrah, Bhadawari, Mehsana, Pandharpuri, Surti, and Toda using ddRAD sequencing protocol. Initially, the genotypes were used to carry out population diversity and structure analysis among the six breeds, followed by pair-wise comparisons of Murrah with the other five breeds through XP-EHH and methodologies to identify regions under selection in Murrah. Admixture results showed significant levels of Murrah inheritance in all the breeds except Pandharpuri. The selection signature analysis revealed six regions in Murrah, which were identified in more than one pair-wise comparison through both XP-EHH and analyses. The significant regions overlapped with QTLs for milk production, immunity, and body development traits. Genes present in these regions included , , , , , , , , , , , , and . These genes emerged as candidates for future polymorphism studies of adaptability and performance traits in buffaloes. The results also suggested ddRAD sequencing as a useful cost-effective alternative for whole-genome sequencing to carry out diversity analysis and discover selection signatures in Indian buffalo breeds.

Citing Articles

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