Review of Current and Future Therapeutics in ABPA

Overview

Journal Ther Adv Chronic Dis

Publisher Sage Publications

Date 2021 Nov 3

PMID 34729149

Citations 7

Authors

Elisa Lewington-Gower

Ley Chan

Anand Shah

Affiliations

Soon will be listed here.

Abstract

Allergic bronchopulmonary aspergillosis is an allergic pulmonary condition caused by hypersensitivity to antigens of found most commonly in patients with underlying asthma or cystic fibrosis. Host factors which alter the innate and adaptive immune responses to this abundant airborne fungus contribute to the development of chronic airway inflammation, bronchiectasis, and fibrosis. Traditionally, treatment has focussed on reducing fungal burden and immune response to fungal antigens. However, a significant proportion of patients continue to suffer recurrent exacerbations with progressive lung damage, and the side effect burden of existing treatments is high. New treatments including novel antifungal agents, monoclonal antibodies against aspects of the adaptive immune response as well as targeted immunotherapies may be better tolerated and achieve improved outcomes but have not yet been studied in large-scale randomised control trials.

Citing Articles

Prevalence and features of allergic bronchopulmonary aspergillosis, United States, 2016-2022.

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Allergic Bronchopulmonary Aspergillosis (ABPA) in the Era of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators.

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