4 Day in Dry Immersion Reproduces Partially the Aging Effect on the Arteries As Observed During 6 Month Spaceflight or Confinement

Overview

Journal NPJ Microgravity

Publisher Springer Nature

Date 2021 Nov 3

PMID 34728651

Citations 4

Authors

Danielle Greaves

Laurent Guillon

Stephane Besnard

Nastassia Navasiolava

Philippe Arbeille

Affiliations

Soon will be listed here.

Abstract

The objectives of this study were to determine whether 4 days of dry immersion (DI) induced similar arterial aging as spaceflight and to test the impact of thigh cuffs. Eighteen subjects underwent DI; nine wore thigh cuffs. Cardiac and arterial targets were assessed by ultrasound. No significant differences were found between the groups. The left ventricle volume, stroke volume (SV), and ejection fraction decreased with DI (p < 0.001). Carotid distensibility reduced (p < 0.05), carotid to femoral arterial tree became stiffer in 33% of the subjects, and femoral artery intima media thickness increased (p < 0.05). A reduction in plasma volume is likely to have caused the observed cardiac changes, whereas the arterial wall changes are probably best explained by hypokinesia and/or environmental stress. These changes are similar but lower in amplitude than those observed in spaceflight and mimic the natural aging effect on earth. The daytime-worn thigh cuffs had no acute or chronic impact on these arterial-focused measurements.

Citing Articles

An Update on Neuroaging on Earth and in Spaceflight.

Kuznetsov N, Statsenko Y, Ljubisavljevic M Int J Mol Sci. 2025; 26(4).

PMID: 40004201 PMC: 11855577. DOI: 10.3390/ijms26041738.

Exercise combined with artificial gravity and exercise only countermeasures prevent organ and blood vessel morpholgical changes induced by 55 days HDT bedrest.

Arbeille P, Zuj K, Guillon L Front Physiol. 2024; 15:1482860.

PMID: 39668842 PMC: 11634870. DOI: 10.3389/fphys.2024.1482860.

Cardiovascular adaptations and pathological changes induced by spaceflight: from cellular mechanisms to organ-level impacts.

Han H, Jia H, Wang Y, Song J Mil Med Res. 2024; 11(1):68.

PMID: 39334239 PMC: 11429428. DOI: 10.1186/s40779-024-00570-3.

4 days in dry immersion increases arterial wall response to ultrasound wave as measured using radio-frequency signal, comparison with spaceflight data.

Arbeille P, Greaves D, Guillon L, Hughson R Front Physiol. 2022; 13:983837.

PMID: 36425297 PMC: 9679644. DOI: 10.3389/fphys.2022.983837.

Cardiovascular deconditioning and impact of artificial gravity during 60-day head-down bed rest-Insights from 4D flow cardiac MRI.

Rabineau J, Issertine M, Hoffmann F, Gerlach D, Caiani E, Haut B Front Physiol. 2022; 13:944587.

PMID: 36277205 PMC: 9586290. DOI: 10.3389/fphys.2022.944587.

References

Arbeille P, Sigaudo D, Pavy le Traon A, Herault S, Porcher M, Gharib C . Femoral to cerebral arterial blood flow redistribution and femoral vein distension during orthostatic tests after 4 days in the head-down tilt position or confinement. Eur J Appl Physiol Occup Physiol. 1998; 78(3):208-18. DOI: 10.1007/s004210050409. View

Arbeille P, Fomina G, Roumy J, Alferova I, Tobal N, Herault S . Adaptation of the left heart, cerebral and femoral arteries, and jugular and femoral veins during short- and long-term head-down tilt and spaceflights. Eur J Appl Physiol. 2002; 86(2):157-68. DOI: 10.1007/s004210100473. View

Dorfman T, Levine B, Tillery T, Peshock R, Hastings J, Schneider S . Cardiac atrophy in women following bed rest. J Appl Physiol (1985). 2007; 103(1):8-16. DOI: 10.1152/japplphysiol.01162.2006. View

Hughson R, Maillet A, Gauquelin G, Arbeille P, Yamamoto Y, Gharib C . Investigation of hormonal effects during 10-h head-down tilt on heart rate and blood pressure variability. J Appl Physiol (1985). 1995; 78(2):583-96. DOI: 10.1152/jappl.1995.78.2.583. View

Arbeille P, Provost R, Zuj K . Carotid and Femoral Arterial Wall Distensibility During Long-Duration Spaceflight. Aerosp Med Hum Perform. 2017; 88(10):924-930. DOI: 10.3357/AMHP.4884.2017. View

Shenkman B, Kozlovskaya I . Cellular Responses of Human Postural Muscle to Dry Immersion. Front Physiol. 2019; 10:187. PMC: 6421338. DOI: 10.3389/fphys.2019.00187. View

Navasiolava N, Custaud M, Tomilovskaya E, Larina I, Mano T, Gauquelin-Koch G . Long-term dry immersion: review and prospects. Eur J Appl Physiol. 2010; 111(7):1235-60. DOI: 10.1007/s00421-010-1750-x. View

Johansen L, Foldager N, Stadeager C, Kristensen M, Bie P, Warberg J . Plasma volume, fluid shifts, and renal responses in humans during 12 h of head-out water immersion. J Appl Physiol (1985). 1992; 73(2):539-44. DOI: 10.1152/jappl.1992.73.2.539. View

Kozlovskaya I, Grigoriev A, Stepantzov V . Countermeasure of the negative effects of weightlessness on physical systems in long-term space flights. Acta Astronaut. 1995; 36(8-12):661-8. DOI: 10.1016/0094-5765(95)00156-5. View

10.

Amirova L, Navasiolava N, Rukavishvikov I, Gauquelin-Koch G, Gharib C, Kozlovskaya I . Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion. Front Physiol. 2020; 11:395. PMC: 7248392. DOI: 10.3389/fphys.2020.00395. View

11.

Perhonen M, Franco F, Lane L, Buckey J, Blomqvist C, Zerwekh J . Cardiac atrophy after bed rest and spaceflight. J Appl Physiol (1985). 2001; 91(2):645-53. DOI: 10.1152/jappl.2001.91.2.645. View

12.

Myerson S, Montgomery H, J World M, Pennell D . Left ventricular mass: reliability of M-mode and 2-dimensional echocardiographic formulas. Hypertension. 2002; 40(5):673-8. DOI: 10.1161/01.hyp.0000036401.99908.db. View

13.

Vinogradova O, Popov D, Saenko I, Kozlovskaya I . Muscle transverse stiffness and venous compliance under conditions of simulated supportlessness. J Gravit Physiol. 2004; 9(1):P327-9. View

14.

Arbeille P, Avan P, Treffel L, Zuj K, Normand H, Denise P . Jugular and Portal Vein Volume, Middle Cerebral Vein Velocity, and Intracranial Pressure in Dry Immersion. Aerosp Med Hum Perform. 2017; 88(5):457-462. DOI: 10.3357/AMHP.4762.2017. View

15.

Herault S, Fomina G, Alferova I, Kotovskaya A, Poliakov V, Arbeille P . Cardiac, arterial and venous adaptation to weightlessness during 6-month MIR spaceflights with and without thigh cuffs (bracelets). Eur J Appl Physiol. 2000; 81(5):384-90. DOI: 10.1007/s004210050058. View

16.

Robin A, Auvinet A, Degryse B, Murphy R, Bareille M, Beck A . DI-5-CUFFS: Venoconstrictive Thigh Cuffs Limit Body Fluid Changes but Not Orthostatic Intolerance Induced by a 5-Day Dry Immersion. Front Physiol. 2020; 11:383. PMC: 7214795. DOI: 10.3389/fphys.2020.00383. View

17.

Watenpaugh D . Analogs of microgravity: head-down tilt and water immersion. J Appl Physiol (1985). 2016; 120(8):904-14. DOI: 10.1152/japplphysiol.00986.2015. View

18.

de Abreu S, Amirova L, Murphy R, Wallace R, Twomey L, Gauquelin-Koch G . Multi-System Deconditioning in 3-Day Dry Immersion without Daily Raise. Front Physiol. 2017; 8:799. PMC: 5645726. DOI: 10.3389/fphys.2017.00799. View

19.

Vinogradova O, Stoida I, Mano T, Iwase S . [Effects of gravitational unloading on blood supply of working muscles]. Aviakosm Ekolog Med. 2002; 36(3):39-46. View

20.

Hughson R, Robertson A, Arbeille P, Shoemaker J, Rush J, Fraser K . Increased postflight carotid artery stiffness and inflight insulin resistance resulting from 6-mo spaceflight in male and female astronauts. Am J Physiol Heart Circ Physiol. 2016; 310(5):H628-38. DOI: 10.1152/ajpheart.00802.2015. View