Acts As an Oncogene in Glioma and Has Diagnostic and Prognostic Values

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2021 Nov 1

PMID 34722629

Citations 4

Authors

Zhenyuan Han

Xiaodong Zhuang

Biao Yang

Lihui Jin

Pengjie Hong

Junqing Xue

Shunjie Chen

Zhen Tian

Affiliations

Soon will be listed here.

Abstract

Gliomas remain one of serious public health problems worldwide which demand further and deeper investigation. The aim of this study was to explore the association between synapse defective protein 1 homolog 1 () and gliomas public database analysis and validation to determine the potential diagnostic and prognostic values. Compared with healthy brain tissues, there was a significant increase in expression in glioma tissues. Additionally, exhibited higher expression levels in glioma patients with unfavorable clinicopathological factors. knockdown of in glioma cell lines A172 inhibited their migrative and invasive ability but not the proliferative ability. GO and KEGG pathway analysis of the top 100 genes coexpressed with showed enrichments of tumor-associated terms. Further bioinformatic analysis revealed that the axis might be involved in glioma development. is expressed at higher levels in gliomas than in healthy brains, and can promote metastasis and invasion but not proliferation of gliomas. Furthermore, has values in the diagnosis and prognosis prediction of gliomas.

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