Hepatitis D: Challenges in the Estimation of True Prevalence and Laboratory Diagnosis

Overview

Journal Gut Pathog

Publisher Biomed Central

Specialty Gastroenterology

Date 2021 Oct 31

PMID 34717740

Citations 14

Authors

Lin-Yuan Chen

Xiao-Yu Pang

Hemant Goyal

Rui-Xia Yang

Hua-Guo Xu

Affiliations

Soon will be listed here.

Abstract

Hepatitis delta virus (HDV) is a defective single negative chain RNA virus, as its envelope protein synthesis is dependent on hepatitis B virus (HBV). Studies have consistently shown that coinfection of HBV and HDV is the most serious form of viral hepatitis, with accelerated progression to liver cirrhosis and hepatocellular carcinoma. About 74 million of HBV surface antigen (HBsAg) positive patients worldwide are also co-infected with HDV. Besides, patients with intravenous drug use and high-risk sexual behavior are at higher risk of HDV infection. Therapeutic schedules for HDV are limited, and relapse of HDV has been observed after treatment with pegylated interferon alpha. To reduce the transmission of HDV, all people infected with HBV should be screened for HDV. At present, several serological and molecular detection methods are widely used in the diagnosis of HDV. However, due to the lack of international standards diagnostic results from different laboratories are often not comparable. Therefore, the true prevalence of HDV is still unclear. In this manuscript, we have analyzed various factors influencing the estimation of HDV prevalence. We have also discussed about the advantages and disadvantages of currently available HDV laboratory diagnostic methods, in order to provide some ideas for improving the detection of HDV.

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References

Bremer B, Anastasiou O, Ciesek S, Wedemeyer H . Automated nucleic acid isolation methods for HDV viral load quantification can lead to viral load underestimation. Antivir Ther. 2018; 24(2):117-123. DOI: 10.3851/IMP3281. View

Chao M, Hsieh S, Taylor J . Role of two forms of hepatitis delta virus antigen: evidence for a mechanism of self-limiting genome replication. J Virol. 1990; 64(10):5066-9. PMC: 247998. DOI: 10.1128/JVI.64.10.5066-5069.1990. View

Evers D, Slemons R, Taubenberger J . Effect of preservative on recoverable RT-PCR amplicon length from influenza A virus in bird feces. Avian Dis. 2008; 51(4):965-8. PMC: 2504707. DOI: 10.1637/7880-012207-RESNOTER1.1. View

Pickett G, Peabody D . Encapsidation of heterologous RNAs by bacteriophage MS2 coat protein. Nucleic Acids Res. 1993; 21(19):4621-6. PMC: 311200. DOI: 10.1093/nar/21.19.4621. View

Karatayli E, Celik Altunoglu Y, Karatayli S, Yurdaydin C, Bozdayi A . Free circulating nucleic acids in plasma and serum as a novel approach to the use of internal controls in real time PCR based detection. J Virol Methods. 2014; 207:133-7. DOI: 10.1016/j.jviromet.2014.07.008. View

Rizzetto M, Canese M, Arico S, Crivelli O, Trepo C, Bonino F . Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers. Gut. 1977; 18(12):997-1003. PMC: 1411847. DOI: 10.1136/gut.18.12.997. View

Hofmann J, Frenzel K, Minh B, von Haeseler A, Edelmann A, Ross S . Quantitative detection and typing of hepatitis D virus in human serum by real-time polymerase chain reaction and melting curve analysis. Diagn Microbiol Infect Dis. 2010; 67(2):172-9. DOI: 10.1016/j.diagmicrobio.2010.02.003. View

. WHO Expert Committee on Biological Standardization. Sixty-third report. World Health Organ Tech Rep Ser. 2014; (980):1-489, back cover. View

Behera B, Mishra R, Thatoi H . Recent biotechnological tools for diagnosis of corona virus disease: A review. Biotechnol Prog. 2020; 37(1):e3078. DOI: 10.1002/btpr.3078. View

10.

Notomi T, Okayama H, Masubuchi H, Yonekawa T, Watanabe K, Amino N . Loop-mediated isothermal amplification of DNA. Nucleic Acids Res. 2000; 28(12):E63. PMC: 102748. DOI: 10.1093/nar/28.12.e63. View

11.

Kleiboeker S . Applications of competitor RNA in diagnostic reverse transcription-PCR. J Clin Microbiol. 2003; 41(5):2055-61. PMC: 154720. DOI: 10.1128/JCM.41.5.2055-2061.2003. View

12.

Schaper M, Rodriguez-Frias F, Jardi R, Tabernero D, Homs M, Ruiz G . Quantitative longitudinal evaluations of hepatitis delta virus RNA and hepatitis B virus DNA shows a dynamic, complex replicative profile in chronic hepatitis B and D. J Hepatol. 2010; 52(5):658-64. DOI: 10.1016/j.jhep.2009.10.036. View

13.

Chen X, Oidovsambuu O, Liu P, Grosely R, Elazar M, Winn V . A novel quantitative microarray antibody capture assay identifies an extremely high hepatitis delta virus prevalence among hepatitis B virus-infected mongolians. Hepatology. 2016; 66(6):1739-1749. PMC: 5441964. DOI: 10.1002/hep.28957. View

14.

Wranke A, Heidrich B, Ernst S, Serrano B, Caruntu F, Curescu M . Anti-HDV IgM as a marker of disease activity in hepatitis delta. PLoS One. 2014; 9(7):e101002. PMC: 4114528. DOI: 10.1371/journal.pone.0101002. View

15.

Pollicino T, Raffa G, Santantonio T, Gaeta G, Iannello G, Alibrandi A . Replicative and transcriptional activities of hepatitis B virus in patients coinfected with hepatitis B and hepatitis delta viruses. J Virol. 2010; 85(1):432-9. PMC: 3014152. DOI: 10.1128/JVI.01609-10. View

16.

Yamashiro T, Nagayama K, Enomoto N, Watanabe H, Miyagi T, Nakasone H . Quantitation of the level of hepatitis delta virus RNA in serum, by real-time polymerase chain reaction--and its possible correlation with the clinical stage of liver disease. J Infect Dis. 2004; 189(7):1151-7. DOI: 10.1086/382133. View

17.

Scholtes C, Icard V, Amiri M, Chevallier-Queyron P, Trabaud M, Ramiere C . Standardized one-step real-time reverse transcription-PCR assay for universal detection and quantification of hepatitis delta virus from clinical samples in the presence of a heterologous internal-control RNA. J Clin Microbiol. 2012; 50(6):2126-8. PMC: 3372137. DOI: 10.1128/JCM.06829-11. View

18.

Wang C, Shen X, Lu J, Zhang L . Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) system for rapid detection of HDV genotype 1. Lett Appl Microbiol. 2012; 56(3):229-35. DOI: 10.1111/lam.12039. View

19.

Giersch K, Bhadra O, Volz T, Allweiss L, Riecken K, Fehse B . Hepatitis delta virus persists during liver regeneration and is amplified through cell division both in vitro and in vivo. Gut. 2017; 68(1):150-157. DOI: 10.1136/gutjnl-2017-314713. View

20.

Mederacke I, Bremer B, Heidrich B, Kirschner J, Deterding K, Bock T . Establishment of a novel quantitative hepatitis D virus (HDV) RNA assay using the Cobas TaqMan platform to study HDV RNA kinetics. J Clin Microbiol. 2010; 48(6):2022-9. PMC: 2884474. DOI: 10.1128/JCM.00084-10. View