A Critical Review of Bile Acids and Their Receptors in Hepatic Encephalopathy

Overview

Journal Anal Biochem

Publisher Elsevier

Specialty Biochemistry

Date 2021 Oct 29

PMID 34715070

Citations 11

Authors

Elaina Williams

Christopher Chu

Sharon DeMorrow

Affiliations

Soon will be listed here.

Abstract

Hepatic encephalopathy describes an array of neurological complications that arise due to liver insufficiency. The pathogenesis of hepatic encephalopathy shares a longstanding association with hyperammonemia and inflammation, and recently, aberrant bile acid signaling has been implicated in the development of key features of hepatic encephalopathy. These key features include neuronal dysfunction, neuroinflammation and blood-brain barrier permeability. This review summarizes the findings of recent studies demonstrating a role for bile acids in the pathogenesis of hepatic encephalopathy via one of three main bile acid receptors and speculates on the possible downstream consequences of aberrant bile acid signaling.

Citing Articles

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