Reactivity of Selected Markers of Innate and Adaptive Immunity in Rabbits Experimentally Infected with Antigenic Variants of RHD (Lagovirus Europaeus/GI.1a)

Overview

Journal Vet Res Commun

Publisher Springer

Specialty Veterinary Medicine

Date 2021 Oct 29

PMID 34713305

Citations 4

Authors

Paulina Niedzwiedzka-Rystwej

Beata Tokarz-Deptula

Wieslaw Deptula

Affiliations

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Abstract

Lagovirus europaeus/GI.1 causes a fatal viral condition in rabbits characterized by acute viral hepatitis and disseminated intravascular coagulation. Due to rapid viral and environmental changes variants (Lagovirus europaeus/GI.1a and GI.2) have appeared and few immunological studies were performed. The aim of the study was to determine innate and adaptive immunity parameters in rabbits infected with six Lagovirus europeus/GI.1a viruses. To achieve the goal several methods were used, i.e. cytometry, microscopy, biochemical and cytochemical tests, spectrophotometry. The results show that three immunotypes exists among the studied strains and they differ in innate (mainly) and adaptive immunity, partly depending on hemagglutination. The peak of changes is 24 h post infection in phagocytosis markers of polymorphonuclear cells and CD8 T cells. Lagovirus europaeus/GI.1a strains differ from Lagovirus europaeus/GI.1 in terms of immunological response based on our previous work concerning the same parameters in immunological response against this disease.

Citing Articles

MicroRNAs Regulate the Expression of Genes Related to the Innate Immune and Inflammatory Response in Rabbits Infected with GI.1 and GI.2 Genotypes.

Ostrycharz-Jasek E, Fitzner A, Siennicka A, Budkowska M, Hukowska-Szematowicz B Int J Mol Sci. 2024; 25(17).

PMID: 39273479 PMC: 11394960. DOI: 10.3390/ijms25179531.

Characterisation of GI-RHDVs (Rabbit Haemorrhagic Disease Viruses) in Terms of Their Pathogenicity and Immunogenicity.

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Neglected Spleen Transcriptional Profile Reveals Inflammatory Disorder Conferred by Rabbit Hemorrhagic Disease Virus 2 Infection.

Yu J, Li Y, Xiao L, Xie J, Guo Z, Ye Y Viruses. 2024; 16(4).

PMID: 38675838 PMC: 11054208. DOI: 10.3390/v16040495.

Occurrence of Lagovirus europaeus (Rabbit Hemorrhagic Disease Virus) in Domestic Rabbits in Southwestern Poland in 2019: Case Report.

Hrynkiewicz R, Bebnowska D, Kauppinen A, Gadd T, Piasecki T, Niedzwiedzka-Rystwej P Microbiol Spectr. 2022; 10(6):e0229822.

PMID: 36445093 PMC: 9769870. DOI: 10.1128/spectrum.02298-22.

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