Application of Homograft Valved Conduit in Cardiac Surgery

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2021 Oct 29

PMID 34712711

Citations 6

Authors

Yige Huyan

Yuan Chang

Jiangping Song

Affiliations

Soon will be listed here.

Abstract

Valved conduits often correct the blood flow of congenital heart disease by connecting the right ventricle to the pulmonary artery (RV-PA). The homograft valved conduit was invented in the 1960s, but its wide application is limited due to the lack of effective sterilization and preservation methods. Modern cryopreservation prolongs the preservation time of homograft valved conduit, which makes it become the most important treatment at present, and is widely used in Ross and other operations. However, homograft valved conduit has limited biocompatibility and durability and lacks any additional growth capacity. Therefore, decellularized valved conduit has been proposed as an effective improved method, which can reduce immune response and calcification, and has potential growth ability. In addition, as a possible substitute, commercial xenograft valved conduit has certain advantages in clinical application, and tissue engineering artificial valved conduit needs to be further studied.

Citing Articles

Allograft valves harvesting and preservation technique for enhanced performance.

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PMID: 40038126 DOI: 10.1007/s10561-025-10165-4.

Advancing Heart Valve Replacement: Risk Mitigation of Decellularized Pulmonary Valve Preparation for Its Implementation in Public Tissue Banks.

Rodriguez Martinez J, Castells-Sala C, Baptista Piteira A, Montagner G, Trojan D, Martinez-Legazpi P Ther Clin Risk Manag. 2025; 21:209-228.

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Ectopic Calcification in Congenital Heart Surgery: A Material-Centric Review.

Watanabe T, Yuhara S, Leland J, Spiess J, Thodla A, Ramachandiran R Pediatr Cardiol. 2024; .

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Vascular Damage and Repair - Are Small-Diameter Vascular Grafts Still the "Holy Grail" of Tissue Engineering?.

Bacakova L, Chlupac J, Filova E, Musilkova J, Tomsu J, Wu Y Physiol Res. 2024; 73(Suppl 1):S335-S363.

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Valved Conduits for Right Ventricular Outflow Tract Reconstruction: A Review of Current Technologies and Future Directions.

Singh S, Faridmoayer E, Vitale N, Woodard E, Xue Y, Abramov A Pediatr Cardiol. 2023; 46(1):14-26.

PMID: 38041710 PMC: 11285445. DOI: 10.1007/s00246-023-03346-z.

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