Retrospective Serological Study of Spp. and Spp. Antibodies in Patients with Peripheral Facial Nerve Palsy

Overview

Journal Infect Ecol Epidemiol

Specialty Microbiology

Date 2021 Oct 29

PMID 34712390

Citations 1

Authors

Katarina Wallmenius

Carl Pahlson

Kenneth Nilsson

Affiliations

Soon will be listed here.

Abstract

In a retrospective study, 36 patients with peripheral facial palsy were serologically evaluated for the presence of spp. and spp. antibodies. All sera underwent immunofluorescence and Western blot analysis for IgG and IgM antibodies using and as antigens. Anti- antibodies were detected using a commercial ELISA detecting and . Three patients (8.3%) were seropositive for spp. with IgG titres equal to 1:128, and six patients (16.7%) had IgM titres equal to or above 1:128. All samples with IgG/IgM titres equal to or above 1:128 were confirmed by Western Blot. Four patients (11.1%) had IgG antibodies against at a titre level normally judged to be indicative of current infection. Two of these patients had significant IgG or IgM titres for both spp. and spp., indicating co-infection. In conclusion, the findings indicate current rickettsial infection or early response at about the same degree as for Lyme borreliosis in patients with facial palsy, but they need to be further examined with a larger number of patients and paired serum analyses.

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References

Gustafson R, Svenungsson B, Gardulf A, Stiernstedt G, Forsgren M . Prevalence of tick-borne encephalitis and Lyme borreliosis in a defined Swedish population. Scand J Infect Dis. 1990; 22(3):297-306. DOI: 10.3109/00365549009027051. View

Oschmann P, DORNDORF W, Hornig C, Schafer C, WELLENSIEK H, Pflughaupt K . Stages and syndromes of neuroborreliosis. J Neurol. 1998; 245(5):262-72. DOI: 10.1007/s004150050216. View

Tveitnes D, Oymar K, Natas O . Acute facial nerve palsy in children: how often is it lyme borreliosis?. Scand J Infect Dis. 2007; 39(5):425-31. DOI: 10.1080/00365540601105764. View

Lindblom A, Wallmenius K, Nordberg M, Forsberg P, Eliasson I, Pahlson C . Seroreactivity for spotted fever rickettsiae and co-infections with other tick-borne agents among habitants in central and southern Sweden. Eur J Clin Microbiol Infect Dis. 2012; 32(3):317-23. PMC: 3569577. DOI: 10.1007/s10096-012-1742-3. View

Baugh R, Basura G, Ishii L, Schwartz S, Drumheller C, Burkholder R . Clinical practice guideline: Bell's palsy. Otolaryngol Head Neck Surg. 2013; 149(3 Suppl):S1-27. DOI: 10.1177/0194599813505967. View

Sekeyova Z, Danchenko M, Filipcik P, Fournier P . Rickettsial infections of the central nervous system. PLoS Negl Trop Dis. 2019; 13(8):e0007469. PMC: 6715168. DOI: 10.1371/journal.pntd.0007469. View

Vander T, Medvedovsky M, Valdman S, Herishanu Y . Facial paralysis and meningitis caused by Rickettsia typhi infection. Scand J Infect Dis. 2004; 35(11-12):886-7. DOI: 10.1080/00365540310016853. View

Severinsson K, Jaenson T, Pettersson J, Falk K, Nilsson K . Detection and prevalence of Anaplasma phagocytophilum and Rickettsia helvetica in Ixodes ricinus ticks in seven study areas in Sweden. Parasit Vectors. 2010; 3:66. PMC: 2923137. DOI: 10.1186/1756-3305-3-66. View

Eppes S . Diagnosis, treatment, and prevention of Lyme disease in children. Paediatr Drugs. 2003; 5(6):363-72. DOI: 10.2165/00128072-200305060-00002. View

10.

Kularatne S, Fernando R, Selvaratnam S, Narampanawa C, Weerakoon K, Wickramasinghe S . Intra-aural tick bite causing unilateral facial nerve palsy in 29 cases over 16 years in Kandy, Sri Lanka: is rickettsial aetiology possible?. BMC Infect Dis. 2018; 18(1):418. PMC: 6106839. DOI: 10.1186/s12879-018-3338-8. View

11.

Jonsson L, Stiernstedt G, Carlson J, Stromberg A, Sjoberg O, Larsson A . Serum and cerebrospinal fluid examinations in the diagnosis of Borrelia infection in Bell's palsy. Acta Otolaryngol. 1990; 110(5-6):421-6. DOI: 10.3109/00016489009107464. View

12.

Nilsson K, Wallmenius K, Hartwig S, Norlander T, Pahlson C . Bell's palsy and sudden deafness associated with Rickettsia spp. infection in Sweden. A retrospective and prospective serological survey including PCR findings. Eur J Neurol. 2013; 21(2):206-14. PMC: 4232316. DOI: 10.1111/ene.12218. View

13.

Sullivan F, Swan I, Donnan P, Morrison J, Smith B, McKinstry B . Early treatment with prednisolone or acyclovir in Bell's palsy. N Engl J Med. 2007; 357(16):1598-607. DOI: 10.1056/NEJMoa072006. View

14.

Ekerfelt C, Masreliez C, Svenvik M, Ernerudh J, ROBERG M, Forsberg P . Antibodies and T-cell reactivity to Borrelia burgdorferi in an asymptomatic population: a study of healthy blood donors in an inland town district in the south-east of Sweden. Scand J Infect Dis. 2002; 33(11):806-8. DOI: 10.1080/00365540110077376. View

15.

Lindblom A, Severinson K, Nilsson K . Rickettsia felis infection in Sweden: report of two cases with subacute meningitis and review of the literature. Scand J Infect Dis. 2010; 42(11-12):906-9. DOI: 10.3109/00365548.2010.508466. View

16.

Walker D, Valbuena G, Olano J . Pathogenic mechanisms of diseases caused by Rickettsia. Ann N Y Acad Sci. 2003; 990:1-11. DOI: 10.1111/j.1749-6632.2003.tb07331.x. View

17.

Bremell D, Hagberg L . Clinical characteristics and cerebrospinal fluid parameters in patients with peripheral facial palsy caused by Lyme neuroborreliosis compared with facial palsy of unknown origin (Bell's palsy). BMC Infect Dis. 2011; 11:215. PMC: 3176206. DOI: 10.1186/1471-2334-11-215. View

18.

Eldin C, Parola P . Rickettsioses as causes of CNS infection in southeast Asia. Lancet Glob Health. 2015; 3(2):e67-8. DOI: 10.1016/S2214-109X(14)70379-1. View

19.

Bitsori M, Galanakis E, Papadakis C, Sbyrakis S . Facial nerve palsy associated with Rickettsia conorii infection. Arch Dis Child. 2001; 85(1):54-5. PMC: 1718833. DOI: 10.1136/adc.85.1.54. View

20.

James D . All that palsies is not Bell's. J R Soc Med. 1996; 89(4):184-7. PMC: 1295731. DOI: 10.1177/014107689608900403. View