Development and Evaluation of PH-sensitive Biodegradable Ternary Blended Hydrogel Films (chitosan/guar Gum/PVP) for Drug Delivery Application

Overview

Journal Sci Rep

Specialty Science

Date 2021 Oct 29

PMID 34711866

Citations 16

Authors

Zunaira Huma Ghauri

Atif Islam

Muhammad Abdul Qadir

Nafisa Gull

Bilal Haider

Rafi Ullah Khan

Tabinda Riaz

Affiliations

Soon will be listed here.

Abstract

pH responsive hydrogels have gained much attraction in biomedical fields. We have formulated ternary hydrogel films as a new carrier of drug. Polyelectrolyte complex of chitosan/guar gum/polyvinyl pyrrolidone cross-linked via sodium tripolyphosphate was developed by solution casting method. Fourier transform infrared spectroscopy, scanning electron microscopy and thermogravimetric analysis were conducted to examine the interactions between the polymeric chains, surface morphology and thermal stability, respectively. The swelling tests resulted that the swelling was reduced with the increase in the concentration of crosslinker due to the more entangled arrangement and less availability of pores in hydrogels. Ciprofloxacin hydrochloride was used as a model drug and its release in simulated gastric fluid, simulated intestinal fluid and phosphate buffer saline solution was studied. pH responsive behaviour of the hydrogels have subjected these hydrogels for drug release applications.

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