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Anterior Cruciate Ligament Reconstruction Using Autologous Hamstrings Augmented With the Ligament Augmentation and Reconstruction System Versus Hamstrings Alone: A Comparative Cohort Study

Overview
Specialty Orthopedics
Date 2021 Oct 28
PMID 34708141
Citations 7
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Abstract

Background: Few studies have reported the return-to-sports (RTS) rate in patients after augmentation of autologous anterior cruciate ligament reconstruction (ACLR) with the Ligament Augmentation and Reconstruction System (LARS).

Purpose/hypothesis: The purpose of this study was to compare postoperative outcomes in patients who underwent ACLR with single-bundle 4-strand hamstring autograft either without augmentation (HA-ACLR group) or with LARS augmentation (AUG-ACLR group). It was hypothesized that clinical outcomes and RTS rates would be better in the AUG-ACLR group at the 1-year follow-up, with similar outcomes in both cohorts by 2 years.

Study Design: Cohort study; Level of evidence, 3.

Methods: Patients who underwent ACLR between April 2014 and December 2017 were included in the current comparative study if they were skeletally mature and had 1- and 2-year follow-up outcomes; patients with concomitant meniscal surgery were also included. Included were 66 patients with AUG-ACLR (mean age, 26.8 years; 67% male) and 130 patients with HA-ACLR (mean age, 27.5 years; 61% male). Subjective outcome measures included the International Knee Documentation Committee Subjective Knee Evaluation Form, Knee injury and Osteoarthritis Outcome Score, Lysholm scale, Tegner activity scale, and the Noyes sports activity rating scale. Objective measures included knee laxity, maximal isokinetic knee flexion and extension strength, and the results of 4 functional hop tests.

Results: There were no significant differences between the study groups in age, sex distribution, body mass index, time to surgery, or number of concurrent meniscal surgeries. At the 1-year follow-up, the AUG-ACLR group had a significantly higher Tegner score ( = .001) and rates of RTS ( = .029) and return to preinjury level of sport ( = .003) compared with the HA-ACLR group. At the 2-year follow-up, there were no differences in these measures between groups. There were no between-group differences in other subjective outcomes, knee laxity, or strength and hop test results at either postoperative time point. There were also no differences in rerupture rates or other complications between the groups.

Conclusion: Patients with AUG-ACLR had higher 1-year postoperative Tegner scores and rates of RTS and preoperative sport level compared with the HA-ACLR group. The 2-year rerupture rate for the AUG-ACLR group was low, and no intra-articular inflammatory complications were noted.

Citing Articles

Anterior Cruciate Ligament Reconstruction with LARS Synthetic Ligament: Outcomes and Failures.

Moretti L, Garofalo R, Cassano G, Geronimo A, Reggente N, Piacquadio F J Clin Med. 2025; 14(1.

PMID: 39797115 PMC: 11721839. DOI: 10.3390/jcm14010032.


Combining an internal tension relieving technique with anterior cruciate ligament reconstruction (ACLR) reduces graft failure rate and improves functional outcomes: a systematic review and meta-analysis.

Wen Y, Huang W, Li M, Jiang Y, Tong Y, Mei H J Orthop Surg Res. 2025; 20(1):19.

PMID: 39773522 PMC: 11705829. DOI: 10.1186/s13018-025-05451-6.


Hamstring tendon graft with LARS augmentation showed superior short-term clinical efficacy compared to hamstring tendon alone as graft in ACL reconstruction: a systematic review and meta-analysis.

Zhao T, Zhang K, Li J, Fu W J Orthop Surg Res. 2024; 19(1):742.

PMID: 39523327 PMC: 11552366. DOI: 10.1186/s13018-024-05234-5.


A comparative analysis of suture-augmented and standard hamstring autograft single-bundle ACL reconstruction outcomes: short-term functional benefits without long-term impact.

Tavakoli Darestani R, Afzal S, Pourmojarab A, Baroutkoub M, Sayyadi S, Barati H BMC Musculoskelet Disord. 2023; 24(1):971.

PMID: 38102582 PMC: 10722839. DOI: 10.1186/s12891-023-07100-7.


There is no difference in the efficacy of anterior cruciate ligament reconstruction using autograft combined with or without ligament augmentation: a systematic review and meta-analysis.

Man Q, Gao Y, Wang H, Ma Y, Meng Q Knee Surg Sports Traumatol Arthrosc. 2023; 31(12):5524-5534.

PMID: 37831110 DOI: 10.1007/s00167-023-07605-7.


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