Comparative Topographical Analysis of Choroidal Microvascular Dropout Between Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy

Overview

Journal Invest Ophthalmol Vis Sci

Specialty Ophthalmology

Date 2021 Oct 27

PMID 34705024

Citations 1

Authors

Eun Jung Lee

Hyun Joo Kee

Kyung-Ah Park

Jong Chul Han

Changwon Kee

Affiliations

Soon will be listed here.

Abstract

Purpose: To identify the presence of choroidal microvascular dropout (MvD) in nonarteritic anterior ischemic optic neuropathy (NAION) eyes and to characterize the topographical distribution for the mechanistic interpretation of MvD development.

Methods: We performed optical coherence tomography angiography on 47 open-angle glaucoma (OAG) and 19 NAION eyes with β-zone peripapillary atrophy (βPPA). We recorded the presence of MvD and compared between the peripapillary topographical measures of MvD, retinal nerve fiber layer (RNFL) defect, and βPPA in angular width and location.

Results: MvD was present in both diseases, marginally more frequently in NAION eyes (19/19, 100.0%) than in OAG eyes (38/47, 80.6%, P = 0.050), without a discernable difference in appearance. NAION eyes also showed wider MvD and RNFL defects compared to OAG eyes (both P < 0.001). In topographical measurements, the distribution of MvD showed a strong correspondence to superimposition areas of βPPA and RNFL defects, more distinctly than to RNFL defects (all P < 0.001). The outline of superimposition area also remarkably resembled the MvD area.

Conclusions: MvD was present in both the OAG and NAION groups. The βPPA-RNFL defect superimposition area topographically and morphologically matched MvD. Further investigations are needed to elucidate the role of RNFL defects in the pathogenesis of MvD and the clinical significance.

Citing Articles

Peripapillary choroidal microvasculature dropout is associated with poor prognosis in optic neuritis.

Lee J, Park S, Kim S, Kim C, Choi W, Lee S PLoS One. 2023; 18(4):e0285017.

PMID: 37104301 PMC: 10138827. DOI: 10.1371/journal.pone.0285017.

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