Genomic Approach to the Assessment of Adverse Effects of Particulate Matters on Skin Cancer and Other Disorders and Underlying Molecular Mechanisms

Overview

Journal J Cancer Prev

Specialty Oncology

Date 2021 Oct 27

PMID 34703818

Citations 1

Authors

Nam Gook Kee

Hyun Soo Kim

Hyunjung Choi

Hyoung-June Kim

Young Rok Seo

Affiliations

Soon will be listed here.

Abstract

Air pollutants are in the spotlight because the human body can easily be exposed to them. Among air pollutants, the particulate matter (PM) represents one of the most serious toxicants that can enter the human body through various exposure routes. PMs have various adverse effects and classified as severe carcinogen by International Agency for Research on Cancer. Their physical and chemical characteristics are distinguished by their size. In this review, we summarized the published information on the physicochemical characteristics and adverse effects of PMs on the skin, including carcinogenicity. Through comparisons of biological networks constructed from relationships discussed in the previous scientific publications, we show it is possible to predict skin cancers and other disorders from particle-size-specific signaling alterations of PM-responsive genes. Our review not only helps to grasp the biological association between ambient PMs and skin diseases including cancer, but also provides new approaches to interpret chemical-gene-disease associations regarding the adverse effects of these heterogeneous particles.

Citing Articles

Association between PM2.5 and skin redness features in Taiwan.

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Particulate matter 10 induces oxidative stress and apoptosis in rhesus macaques skin fibroblast.

Lee J, Kwon J, Jo Y, Yoon S, Hyeon J, Park B PeerJ. 2023; 11:e16589.

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