Short-term Cardiovascular Complications of Multi-system Inflammatory Syndrome in Children (MIS-C) in Adolescents and Children

Overview

Journal Curr Pediatr Rep

Specialty Pediatrics

Date 2021 Oct 27

PMID 34703656

Citations 17

Authors

Omar I Hejazi

Yue-Hin Loke

Ashraf S Harahsheh

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: We provide the readers with a review of cardiac complications in children with multi-system inflammatory syndrome in children (MIS-C) and its short-term outcomes.

Recent Findings: Recent reports described the acute cardiac manifestations of MIS-C in children and provided a glimpse of the short-term outcomes.

Summary: Children with MIS-C have been reported to acutely have variable degrees of cardiac findings including abnormal cardiac enzymes, abnormal electrocardiographs, decreased systolic function, coronary artery abnormalities from coronary dilation to giant aneurysms, mitral valve regurgitation, tricuspid valve regurgitation, aortic valve insufficiency, pericardial effusion, diastolic dysfunction, abnormal cardiac strain, and abnormal cardiac MRI. The majority of these abnormalities resolved during short-term follow-up. Further studies are needed to assess if transient or persistent cardiac complications are associated with long-term adverse cardiac events in children with MIS-C.

Supplementary Information: The online version contains supplementary material available at 10.1007/s40124-021-00258-5.

Citing Articles

Effectiveness of early Anakinra on cardiac function in children with multisystem inflammatory syndrome of COVID-19: a systematic review.

Shabil M, Khatib M, Banda G, Zahiruddin Q, Ballal S, Bansal P BMC Infect Dis. 2024; 24(1):847.

PMID: 39169304 PMC: 11337762. DOI: 10.1186/s12879-024-09581-w.

Longitudinal Cardiac Evaluation of Children with Multisystem Inflammatory Syndrome (MIS-C) Following COVID-19 by Conventional and Speckle-Tracking Echocardiography.

Anagnostopoulou A, Dourdouna M, Loukopoulou S, Mpourazani E, Poulakis M, Karanasios E Pediatr Cardiol. 2024; 45(5):1110-1119.

PMID: 38372778 PMC: 11056331. DOI: 10.1007/s00246-023-03375-8.

Evaluation of late cardiac effects after multisystem inflammatory syndrome in children.

De Wolf R, Zaqout M, Tanaka K, Muino-Mosquera L, van Berlaer G, Vandekerckhove K Front Pediatr. 2023; 11:1253608.

PMID: 37691776 PMC: 10484557. DOI: 10.3389/fped.2023.1253608.

Echocardiographic Findings in Children with Multisystem Inflammatory Syndrome from Initial Presentation to the First Years after Discharge.

Bulut M, Ekici F, Tural Kara T, Ulgen Tekerek N, Akbay S, Mutlu Z Turk Arch Pediatr. 2023; 58(5):546-552.

PMID: 37670554 PMC: 10541517. DOI: 10.5152/TurkArchPediatr.2023.23070.

Short- and mid-term outcomes of multisystem inflammatory syndrome in children: a longitudinal prospective single-center cohort study.

Roge I, kivite-Urtane A, Smane L, Meiere A, Klavina L, Barzdina E Front Pediatr. 2023; 11:1223266.

PMID: 37650048 PMC: 10465300. DOI: 10.3389/fped.2023.1223266.

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