Role of Formin INF2 in Human Diseases

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2021 Oct 26

PMID 34698992

Citations 10

Authors

Yiting Zhao

Hui Zhang

Haibiao Wang

Meng Ye

Xiaofeng Jin

Affiliations

Soon will be listed here.

Abstract

Formin proteins catalyze actin nucleation and microfilament polymerization. Inverted formin 2 (INF2) is an atypical diaphanous-related formin characterized by polymerization and depolymerization of actin. Accumulating evidence showed that INF2 is associated with kidney disease focal segmental glomerulosclerosis and cancers, such as colorectal and thyroid cancer where it functions as a tumor suppressor, glioblastoma, breast, prostate, and gastric cancer, via its oncogenic function. However, studies on the underlying molecular mechanisms of the different roles of INF2 in diverse cancers are limited. This review comprehensively describes the structure, biochemical features, and primary pathogenic mutations of INF2.

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