Mouse Genome Informatics (MGI): Latest News from MGD and GXD

Overview

Journal Mamm Genome

Specialty Genetics

Date 2021 Oct 26

PMID 34698891

Citations 25

Authors

Martin Ringwald

Joel E Richardson

Richard M Baldarelli

Judith A Blake

James A Kadin

Cynthia Smith

Carol J Bult

Affiliations

Soon will be listed here.

Abstract

The Mouse Genome Informatics (MGI) database system combines multiple expertly curated community data resources into a shared knowledge management ecosystem united by common metadata annotation standards. MGI's mission is to facilitate the use of the mouse as an experimental model for understanding the genetic and genomic basis of human health and disease. MGI is the authoritative source for mouse gene, allele, and strain nomenclature and is the primary source of mouse phenotype annotations, functional annotations, developmental gene expression information, and annotations of mouse models with human diseases. MGI maintains mouse anatomy and phenotype ontologies and contributes to the development of the Gene Ontology and Disease Ontology and uses these ontologies as standard terminologies for annotation. The Mouse Genome Database (MGD) and the Gene Expression Database (GXD) are MGI's two major knowledgebases. Here, we highlight some of the recent changes and enhancements to MGD and GXD that have been implemented in response to changing needs of the biomedical research community and to improve the efficiency of expert curation. MGI can be accessed freely at http://www.informatics.jax.org .

Citing Articles

Computational modeling of human genetic variants in mice.

Dong K, Gould S, Li M, Sanchez Rivera F bioRxiv. 2025; .

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ENQUIRE automatically reconstructs, expands, and drives enrichment analysis of gene and Mesh co-occurrence networks from context-specific biomedical literature.

Musella L, Afonso Castro A, Lai X, Widmann M, Vera J PLoS Comput Biol. 2025; 21(2):e1012745.

PMID: 39932993 PMC: 11844901. DOI: 10.1371/journal.pcbi.1012745.

Standardized pipelines support and facilitate integration of diverse datasets at the Rat Genome Database.

Smith J, Tutaj M, Thota J, Lamers L, Gibson A, Kundurthi A Database (Oxford). 2025; 2025.

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Characterization and automated classification of sentences in the biomedical literature: a case study for biocuration of gene expression and protein kinase activity.

Raciti D, Van Auken K, Arnaboldi V, Tabone C, Muller H, Sternberg P bioRxiv. 2025; .

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Identification of novel nutrient sensitive human yolk sac functions required for embryogenesis.

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