Nonhuman Primate Models of Zika Virus Infection and Disease During Pregnancy

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Oct 26

PMID 34696518

Citations 14

Authors

Nicole N Haese

Victoria H J Roberts

Athena Chen

Daniel N Streblow

Terry K Morgan

Alec J Hirsch

Affiliations

Soon will be listed here.

Abstract

Since the explosive outbreak of Zika virus in Brazil and South/Central America in 2015-2016, the frequency of infections has subsided, but Zika virus remains present in this region as well as other tropical and sub-tropical areas of the globe. The most alarming aspect of Zika virus infection is its association with severe birth defects when infection occurs in pregnant women. Understanding the mechanism of Zika virus pathogenesis, which comprises features unique to Zika virus as well as shared with other teratogenic pathogens, is key to future prophylactic or therapeutic interventions. Nonhuman primate-based research has played a significant role in advancing our knowledge of Zika virus pathogenesis, especially with regard to fetal infection. This review summarizes what we have learned from these models and potential future research directions.

Citing Articles

Nonhuman primate models of pediatric viral diseases.

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Fetal Zika virus inoculation in macaques revealed control of the fetal viral load during pregnancy.

Egloff C, Fovet C, Denis J, Pascal Q, Bossevot L, Luccantoni S Virol J. 2024; 21(1):209.

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Applications and advancements in animal models for antiviral research on mosquito-borne arboviruses.

Tang M, Wong K, Azman A, Lani R Animal Model Exp Med. 2024; 7(5):673-684.

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Disruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection.

Tisoncik-Go J, Stokes C, Whitmore L, Newhouse D, Voss K, Gustin A Nat Commun. 2024; 15(1):5173.

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Pathogenesis of viral infections during pregnancy.

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