Real-Time Genomic Surveillance During the 2021 Re-Emergence of the Yellow Fever Virus in Rio Grande Do Sul State, Brazil

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Oct 26

PMID 34696408

Citations 14

Authors

Miguel de S Andrade

Fabricio S Campos

Aline A S Campos

Filipe V S Abreu

Fernando L Melo

Anaia da P Seva

Jader da C Cardoso

Edmilson Dos Santos

Lucas C Born

Claudia M D da Silva

Nicolas F D Muller

Cirilo H de Oliveira

Alex J J da Silva

Danilo Simonini-Teixeira

Sofia Bernal-Valle

Maria A M M Mares-Guia

George R Albuquerque

Alessandro P M Romano

Ana C Franco

Bergmann M Ribeiro

Paulo M Roehe

Marco A B de Almeida

Affiliations

Soon will be listed here.

Abstract

The 2021 re-emergence of yellow fever in non-human primates in the state of Rio Grande do Sul (RS), southernmost Brazil, resulted in the death of many howler monkeys (genus ) and led the state to declare a Public Health Emergency of State Importance, despite no human cases reported. In this study, near-complete genomes of yellow fever virus (YFV) recovered from the outbreak were sequenced and examined aiming at a better understanding of the phylogenetic relationships and the spatio-temporal dynamics of the virus distribution. Our results suggest that the most likely sequence of events involved the reintroduction of YFV from the state of São Paulo to RS through the states of Paraná and Santa Catarina, by the end of 2020. These findings reinforce the role of genomic surveillance in determining the pathways of distribution of the virus and in providing references for the implementation of preventive measures for populations in high risk areas.

Citing Articles

Exploring environmental and climate features associated with yellow fever across space and time in the Brazilian Atlantic Forest biome.

Kersul M, Abreu F, Pinter A, Campos F, Andrade M, Teixeira D PLoS One. 2024; 19(10):e0308560.

PMID: 39374224 PMC: 11458019. DOI: 10.1371/journal.pone.0308560.

Insect cell production of chimeric virus-like particles based on human immunodeficiency virus GAG proteins and yellow fever virus envelope protein.

da Silva Morgado F, Cahu R, de Jesus D, de Souza Chaves L, Ribeiro B Braz J Microbiol. 2024; 55(4):3187-3197.

PMID: 39254800 PMC: 11711793. DOI: 10.1007/s42770-024-01509-5.

YELLOW ALERT: Persistent Yellow Fever Virus Circulation among Non-Human Primates in Urban Areas of Minas Gerais State, Brazil (2021-2023).

Garcia-Oliveira G, Guimaraes A, Moreira G, Costa T, Arruda M, de Mello E Viruses. 2024; 16(1).

PMID: 38257732 PMC: 10818614. DOI: 10.3390/v16010031.

Arbovirus surveillance in mosquitoes: Historical methods, emerging technologies, and challenges ahead.

Maia L, Oliveira C, Silva A, Souza P, Muller N, da Cruz Cardoso J Exp Biol Med (Maywood). 2024; 248(22):2072-2082.

PMID: 38183286 PMC: 10800135. DOI: 10.1177/15353702231209415.

Case report: Urbanized non-human primates as sentinels for human zoonotic diseases: a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus.

Sousa D, Wilson T, Macedo I, Romano A, Ramos D, Passos P Front Public Health. 2023; 11:1236384.

PMID: 37670831 PMC: 10475956. DOI: 10.3389/fpubh.2023.1236384.

References

da C Cardoso J, Almeida M, Dos Santos E, da Fonseca D, Sallum M, Noll C . Yellow fever virus in Haemagogus leucocelaenus and Aedes serratus mosquitoes, southern Brazil, 2008. Emerg Infect Dis. 2010; 16(12):1918-24. PMC: 3294583. DOI: 10.3201/eid1612.100608. View

Giovanetti M, de Mendonca M, Fonseca V, Mares-Guia M, Fabri A, Xavier J . Yellow Fever Virus Reemergence and Spread in Southeast Brazil, 2016-2019. J Virol. 2019; 94(1). PMC: 6912119. DOI: 10.1128/JVI.01623-19. View

de Oliveira Figueiredo P, Stoffella-Dutra A, Barbosa Costa G, de Oliveira J, Amaral C, Santos J . Re-Emergence of Yellow Fever in Brazil during 2016-2019: Challenges, Lessons Learned, and Perspectives. Viruses. 2020; 12(11). PMC: 7692154. DOI: 10.3390/v12111233. View

Faria N, Kraemer M, Hill S, Goes de Jesus J, Aguiar R, Iani F . Genomic and epidemiological monitoring of yellow fever virus transmission potential. Science. 2018; 361(6405):894-899. PMC: 6874500. DOI: 10.1126/science.aat7115. View

de Jesus J, Graf T, Giovanetti M, Mares-Guia M, Xavier J, Lima Maia M . Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil. PLoS Negl Trop Dis. 2020; 14(8):e0008405. PMC: 7418952. DOI: 10.1371/journal.pntd.0008405. View

P Monath T, Vasconcelos P . Yellow fever. J Clin Virol. 2014; 64:160-73. DOI: 10.1016/j.jcv.2014.08.030. View

Rosa M, Brancalion P, Crouzeilles R, Tambosi L, Piffer P, Lenti F . Hidden destruction of older forests threatens Brazil's Atlantic Forest and challenges restoration programs. Sci Adv. 2021; 7(4). PMC: 7817092. DOI: 10.1126/sciadv.abc4547. View

Almeida M, da C Cardoso J, Dos Santos E, da Fonseca D, Cruz L, Faraco F . Surveillance for yellow Fever virus in non-human primates in southern Brazil, 2001-2011: a tool for prioritizing human populations for vaccination. PLoS Negl Trop Dis. 2014; 8(3):e2741. PMC: 3953010. DOI: 10.1371/journal.pntd.0002741. View

Abreu F, Delatorre E, Dos Santos A, Ferreira-de-Brito A, de Castro M, Pereira Ribeiro I . Combination of surveillance tools reveals that Yellow Fever virus can remain in the same Atlantic Forest area at least for three transmission seasons. Mem Inst Oswaldo Cruz. 2019; 114:e190076. PMC: 6489371. DOI: 10.1590/0074-02760190076. View

10.

de Rezende I, Sacchetto L, de Mello E, Augusto Alves P, de Melo Iani F, Adelino T . Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018. PLoS Negl Trop Dis. 2018; 12(6):e0006538. PMC: 6002110. DOI: 10.1371/journal.pntd.0006538. View

11.

Vasconcelos P, Bryant J, da Rosa T, Tesh R, Rodrigues S, Barrett A . Genetic divergence and dispersal of yellow fever virus, Brazil. Emerg Infect Dis. 2004; 10(9):1578-84. PMC: 3320275. DOI: 10.3201/eid1009.040197. View

12.

Tardif S, Coleman K, Hobbs T, Lutz C . IACUC review of nonhuman primate research. ILAR J. 2013; 54(2):234-45. PMC: 3814393. DOI: 10.1093/ilar/ilt040. View

13.

Delatorre E, Abreu F, Pereira Ribeiro I, Gomez M, Dos Santos A, Ferreira-de-Brito A . Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018. Front Microbiol. 2019; 10:1079. PMC: 6543907. DOI: 10.3389/fmicb.2019.01079. View

14.

Romano A, Costa Z, Ramos D, Andrade M, de Sa Jayme V, Barreto de Almeida M . Yellow Fever outbreaks in unvaccinated populations, Brazil, 2008-2009. PLoS Negl Trop Dis. 2014; 8(3):e2740. PMC: 3953027. DOI: 10.1371/journal.pntd.0002740. View

15.

Possas C, Lourenco-de-Oliveira R, Tauil P, De Paula Pinheiro F, Pissinatti A, da Cunha R . Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunisation. Mem Inst Oswaldo Cruz. 2018; 113(10):e180278. PMC: 6135548. DOI: 10.1590/0074-02760180278. View

16.

Katoh K, Standley D . MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Mol Biol Evol. 2013; 30(4):772-80. PMC: 3603318. DOI: 10.1093/molbev/mst010. View

17.

Cunha M, Duarte-Neto A, Zaki Pour S, Ortiz-Baez A, cerny J, Pereira B . Origin of the São Paulo Yellow Fever epidemic of 2017-2018 revealed through molecular epidemiological analysis of fatal cases. Sci Rep. 2020; 9(1):20418. PMC: 6938505. DOI: 10.1038/s41598-019-56650-1. View

18.

Moreno E, Spinola R, Tengan C, Brasil R, Siciliano M, Coimbra T . Yellow fever epizootics in non-human primates, São Paulo state, Brazil, 2008-2009. Rev Inst Med Trop Sao Paulo. 2013; 55(1):45-50. DOI: 10.1590/s0036-46652013000100008. View

19.

Barreto de Almeida M, Dos Santos E, da Cruz Cardoso J, da Fonseca D, Noll C, Silveira V . Yellow fever outbreak affecting Alouatta populations in southern Brazil (Rio Grande do Sul State), 2008-2009. Am J Primatol. 2011; 74(1):68-76. DOI: 10.1002/ajp.21010. View

20.

Gomez M, Abreu F, Dos Santos A, de Mello I, Santos M, Pereira Ribeiro I . Genomic and structural features of the yellow fever virus from the 2016-2017 Brazilian outbreak. J Gen Virol. 2018; 99(4):536-548. DOI: 10.1099/jgv.0.001033. View