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Immunosuppressant Management in Renal Transplant Patients with COVID-19

Overview
Journal Biomed Res Int
Publisher Wiley
Date 2021 Oct 25
PMID 34692845
Citations 5
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Abstract

The coronavirus disease 2019 (COVID-19) pandemic poses a special risk for both immunosuppressed patients, especially transplant recipients. Although the knowledge about this infection is growing, many uncertainties remain, particularly regarding the kidney. Kidney transplant recipients (KDRs) should be considered immunocompromised hosts since a potential risk for infection, comorbidity, and immunosuppression exposure exists. Additionally, the management of immunosuppressive agents in KDRs remains challenging. Potential drug interactions with immunosuppressive treatment escalated the risk of unwanted side effects. In this review, we aimed to attain an augmented awareness and improved management immunosuppressant for COVID-19 KDRs.

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References
1.
Kumar D, Tellier R, Draker R, Levy G, Humar A . Severe Acute Respiratory Syndrome (SARS) in a liver transplant recipient and guidelines for donor SARS screening. Am J Transplant. 2003; 3(8):977-81. PMC: 7175989. DOI: 10.1034/j.1600-6143.2003.00197.x. View

2.
Miarons M, Larrosa-Garcia M, Garcia-Garcia S, Los-Arcos I, Moreso F, Berastegui C . COVID-19 in Solid Organ Transplantation: A Matched Retrospective Cohort Study and Evaluation of Immunosuppression Management. Transplantation. 2020; 105(1):138-150. DOI: 10.1097/TP.0000000000003460. View

3.
Lu X, Chen T, Wang Y, Wang J, Yan F . Adjuvant corticosteroid therapy for critically ill patients with COVID-19. Crit Care. 2020; 24(1):241. PMC: 7235543. DOI: 10.1186/s13054-020-02964-w. View

4.
Pascual J, Berger S, Witzke O, Tedesco H, Mulgaonkar S, Qazi Y . Everolimus with Reduced Calcineurin Inhibitor Exposure in Renal Transplantation. J Am Soc Nephrol. 2018; 29(7):1979-1991. PMC: 6050928. DOI: 10.1681/ASN.2018010009. View

5.
Cheung C, Poon L, Ng I, Luk W, Sia S, Wu M . Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis. J Virol. 2005; 79(12):7819-26. PMC: 1143636. DOI: 10.1128/JVI.79.12.7819-7826.2005. View