Extracellular Vesicles in Acute Leukemia: A Mesmerizing Journey With a Focus on Transferred MicroRNAs

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Oct 25

PMID 34692712

Citations 9

Authors

Mehrdad Izadirad

Zoufang Huang

Farideh Jafari

Amir Ali Hamidieh

Ahmad Gharehbaghian

Yi-Dong Li

Leila Jafari

Zhe-Sheng Chen

Affiliations

Soon will be listed here.

Abstract

Despite their small size, the membrane-bound particles named extracellular vesicles (EVs) seem to play an enormous role in the pathogenesis of acute leukemia. From oncogenic hematopoietic stem cells (HSCs) to become leukemic cells to alter the architecture of bone marrow (BM) microenvironment, EVs are critical components of leukemia development. As a carrier of essential molecules, especially a group of small non-coding RNAs known as miRNA, recently, EVs have attracted tremendous attention as a prognostic factor. Given the importance of miRNAs in the early stages of leukemogenesis and also their critical parts in the development of drug-resistant phenotype, it seems that the importance of EVs in the development of leukemia is more than what is expected. To be familiar with the clinical value of leukemia-derived EVs, this review aimed to briefly shed light on the biology of EVs and to discuss the role of EV-derived miRNAs in the development of acute myeloid leukemia and acute lymphoblastic leukemia. By elaborating the advances and challenges concerning the isolation of EVs, we discuss whether EVs could have a prognostic value in the clinical setting for leukemia.

Citing Articles

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