The Change of Gut Microbiota-derived Short-chain Fatty Acids in Diabetic Kidney Disease

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2021 Oct 24

PMID 34689373

Citations 16

Authors

Chenyu Zhong

Zhiwei Dai

Lingxiong Chai

Lingping Wu

Jianhui Li

Weiying Guo

Jie Zhang

Qun Zhang

Congping Xue

Haixue Lin

Qun Luo

Kedan Cai

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies found the dysbiosis of intestinal microbiota in diabetic kidney disease (DKD), especially the decreased SCFA-producing bacteria. We aimed to investigate the concentration of the stool and serum short-chain fatty acids (SCFAs), gut microbiota-derived metabolites, in individuals with DKD and reveal the correlations between SCFAs and renal function.

Methods: A total of 30 participants with DKD, 30 participants with type 2 diabetes mellitus (DM), and 30 normal controls (NC) in HwaMei Hospital were recruited from 1/1/2018 to 12/31/2019. Participants with DKD were divided into low estimated glomerular filtration rate (eGFR)(eGFR<60ml/min, n=14) and high eGFR (eGFR≥60ml/min, n=16) subgroups. Stool and serum were measured for SCFAs with gas chromatograph-mass spectrometry.

Results: The DKD group showed markedly lower levels of fecal acetate, propionate, and butyrate versus NC (p<0.001, p<0.001, p=0.018, respectively) [1027.32(784.21-1357.90)]vs[2064.59(1561.82-2637.44)]μg/g,[929.53(493.65-1344.26)]vs[1684.57(1110.54-2324.69)]μg/g,[851.39(409.57-1611.65)] vs[1440.74(1004.15-2594.73)]μg/g, respectively, and the lowest fecal total SCFAs concentration among the groups. DKD group also had a lower serum caproate concentration than that with diabetes (p=0.020)[0.57(0.47-0.61)]vs[0.65(0.53-0.79)]μmol/L. In the univariate regression analysis, fecal and serum acetate correlated with eGFR (OR=1.013, p=0.072; OR=1.017, p=0.032). The correlation between serum total SCFAs and eGFR showed statistical significance (OR=1.019, p=0.024) unadjusted and a borderline significance (OR=1.024, p=0.063) when adjusted for Hb and LDL. The decrease in serum acetate and total SCFAs were found of borderline significant difference in both subgroups (p=0.055, p=0.050).

Conclusion: This study provides evidence that in individuals with DKD, serum and fecal SCFAs levels (fecal level in particular) were lowered, and there was a negative correlation between SCFAs and renal function.

Citing Articles

Circulating short-chain and branched short-chain fatty acids and the risk of incident type 2 diabetes: findings from the 4C study.

Wang S, Lin H, Jia X, Lin Y, Hu C, Li M Life Metab. 2025; 4(2):loaf001.

PMID: 40078932 PMC: 11897982. DOI: 10.1093/lifemeta/loaf001.

Short-Chain Fatty Acids and Their Metabolic Interactions in Heart Failure.

Chulenbayeva L, Issilbayeva A, Sailybayeva A, Bekbossynova M, Kozhakhmetov S, Kushugulova A Biomedicines. 2025; 13(2).

PMID: 40002756 PMC: 11853371. DOI: 10.3390/biomedicines13020343.

Genetic Evidence for the Causal Relationship Between Gut Microbiota and Diabetic Kidney Disease: A Bidirectional, Two-Sample Mendelian Randomisation Study.

Zhang Y, Zhao L, Jia Y, Zhang X, Han Y, Lu P J Diabetes Res. 2024; 2024:4545595.

PMID: 39479291 PMC: 11524706. DOI: 10.1155/2024/4545595.

Double-side role of short chain fatty acids on host health via the gut-organ axes.

Gao Y, Yao Q, Meng L, Wang J, Zheng N Anim Nutr. 2024; 18:322-339.

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Guild-level signature of gut microbiome for diabetic kidney disease.

Tang S, Wu G, Liu Y, Xue B, Zhang S, Zhang W mBio. 2024; 15(7):e0073524.

PMID: 38819146 PMC: 11253615. DOI: 10.1128/mbio.00735-24.

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