CaMKIIα Knockout Protects from Ischemic Neuronal Cell Death After Resuscitation from Cardiac Arrest

Overview

Journal Brain Res

Specialty Neurology

Date 2021 Oct 23

PMID 34687697

Citations 4

Authors

Nicole L Rumian

Nicholas E Chalmers

Jonathan E Tullis

Paco S Herson

K Ulrich Bayer

Affiliations

Soon will be listed here.

Abstract

CaMKIIα plays a dual role in synaptic plasticity, as it can mediate synaptic changes in opposing directions. We hypothesized that CaMKIIα plays a similar dual role also in neuronal cell death and survival. Indeed, the CaMKII inhibitor tatCN21 is neuroprotective when added during or after excitotoxic/ischemic insults, but was described to cause sensitization when applied long-term prior to such insult. However, when comparing long-term CaMKII inhibition by several different inhibitors in neuronal cultures, we did not detect any sensitization. Likewise, in a mouse in vivo model of global cerebral ischemia (cardiac arrest followed by cardiopulmonary resuscitation), complete knockout of the neuronal CaMKIIα isoform did not cause sensitization but instead significant neuroprotection.

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