Sirtuins As Interesting Players in the Course of HIV Infection and Comorbidities

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2021 Oct 23

PMID 34685718

Citations 8

Authors

Karolina Jurkowska

Beata Szymanska

Brygida Knysz

Amadeusz Kuzniarski

Agnieszka Piwowar

Affiliations

Soon will be listed here.

Abstract

The sirtuins (SIRTs) are a family of enzymes from the group of NAD-dependent deacetylases. Through the reaction of splitting the acetyl group of various transcription factors and histones they regulate many processes in the organism. The activity of sirtuins is linked to metabolic control, oxidative stress, inflammation and apoptosis, and they also affect the course of viral infections. For this reason, they may participate in the pathogenesis and development of many diseases, but little is known about their role in the course of human immunodeficiency virus (HIV) infection, which is the subject of this review. In the course of HIV infection, comorbidities such as: neurodegenerative disorders, obesity, insulin resistance and diabetes, lipid disorders and cardiovascular diseases, renal and bone diseases developed more frequently and faster compared to the general population. The role of sirtuins in the development of accompanying diseases in the course of HIV infection may also be interesting. There is still a lack of detailed information on this subject. The role of sirtuins, especially SIRT1, SIRT3, SIRT6, are indicated to be of great importance in the course of HIV infection and the development of the abovementioned comorbidities.

Citing Articles

Assessment of Metabolic, Inflammatory, and Immunological Disorders Using a New Panel of Plasma Parameters in People Living with HIV Undergoing Antiretroviral Therapy-A Retrospective Study.

Szymanska B, Knysz B, Cieplucha H, Piwowar A J Clin Med. 2024; 13(15).

PMID: 39124846 PMC: 11312710. DOI: 10.3390/jcm13154580.

Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction.

Duran-Castells C, Llano A, Kawana-Tachikawa A, Prats A, Martinez-Zalacain I, Kobayashi-Ishihara M J Virol. 2023; 97(2):e0165522.

PMID: 36719240 PMC: 9972991. DOI: 10.1128/jvi.01655-22.

HIV-Associated Insults Modulate ADAM10 and Its Regulator Sirtuin1 in an NMDA Receptor-Dependent Manner.

Lopez Lloreda C, Chowdhury S, Ghura S, Alvarez-Periel E, Jordan-Sciutto K Cells. 2022; 11(19).

PMID: 36230925 PMC: 9564041. DOI: 10.3390/cells11192962.

Virtual Screening in the Identification of Sirtuins' Activity Modulators.

Abbotto E, Scarano N, Piacente F, Millo E, Cichero E, Bruzzone S Molecules. 2022; 27(17).

PMID: 36080416 PMC: 9457788. DOI: 10.3390/molecules27175641.

Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy.

Ahodantin J, Nio K, Funaki M, Zhai X, Wilson E, Kottilil S JCI Insight. 2022; 7(13).

PMID: 35639478 PMC: 9310524. DOI: 10.1172/jci.insight.152738.

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