Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2021 Oct 23

PMID 34685323

Citations 4

Authors

Qian Tao

Julong Zhong

Rui Wang

Yuzhu Huang

Affiliations

Soon will be listed here.

Abstract

Both ionic and enzymatic crosslink are efficient strategies for constructing network materials of high biocompatibility. Here chitosan was modified firstly and then crosslinked by these two methods for complementary advantages. The preparation methods and ionic crosslinkers can regulate the size and uniformity of the multiple-crosslinked nanogels. The multiple-crosslinked nanogels with the smallest size and the best uniformity was selected for the drug delivery. The drug-loading content and encapsulation efficiency were up to 35.01 and 66.82%, respectively. Their release behaviours are correlated with the pH value and the drug dosage. In general, the lower pH value and the lower drug dosage promoted the drug release. With the assistance of several kinetic models, it is found that drug diffusion plays a preponderant role in drug release, while polymer relaxation has a subtle effect. The multiple-crosslink resulting from ionic compounds and enzymes may provide a new perspective on developing novel biocompatible materials.

Citing Articles

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications.

Taokaew S, Kaewkong W, Kriangkrai W Gels. 2023; 9(4).

PMID: 37102889 PMC: 10138304. DOI: 10.3390/gels9040277.

Crisaborole Loaded Nanoemulsion Based Chitosan Gel: Formulation, Physicochemical Characterization and Wound Healing Studies.

Ansari M, Soliman G, Ur Rehman N, Anwer M Gels. 2022; 8(5).

PMID: 35621616 PMC: 9140491. DOI: 10.3390/gels8050318.

Development of Apremilast Nanoemulsion-Loaded Chitosan Gels: In Vitro Evaluations and Anti-Inflammatory and Wound Healing Studies on a Rat Model.

Ahmed M, Anwer M, Fatima F, Alali A, Kalam M, Zafar A Gels. 2022; 8(5).

PMID: 35621551 PMC: 9141762. DOI: 10.3390/gels8050253.

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences.

Papagiannopoulos A, Sotiropoulos K Polymers (Basel). 2022; 14(4).

PMID: 35215726 PMC: 8963082. DOI: 10.3390/polym14040813.

References

Kurisawa M, Chung J, Yang Y, Gao S, Uyama H . Injectable biodegradable hydrogels composed of hyaluronic acid-tyramine conjugates for drug delivery and tissue engineering. Chem Commun (Camb). 2005; (34):4312-4. DOI: 10.1039/b506989k. View

Kong B, Kim A, Park S . Properties and in vitro drug release of hyaluronic acid-hydroxyethyl cellulose hydrogels for transdermal delivery of isoliquiritigenin. Carbohydr Polym. 2016; 147:473-481. DOI: 10.1016/j.carbpol.2016.04.021. View

Guo F, Li G, Zhou H, Ma S, Guo L, Liu X . Temperature and HO-operated nano-valves on mesoporous silica nanoparticles for controlled drug release and kinetics. Colloids Surf B Biointerfaces. 2019; 187:110643. DOI: 10.1016/j.colsurfb.2019.110643. View

Roberts J, Naudiyal P, Lim K, Poole-Warren L, Martens P . A comparative study of enzyme initiators for crosslinking phenol-functionalized hydrogels for cell encapsulation. Biomater Res. 2016; 20:30. PMC: 5050849. DOI: 10.1186/s40824-016-0077-z. View

Liu J, Pu H, Liu S, Kan J, Jin C . Synthesis, characterization, bioactivity and potential application of phenolic acid grafted chitosan: A review. Carbohydr Polym. 2017; 174:999-1017. DOI: 10.1016/j.carbpol.2017.07.014. View

Lee F, Bae K, Kurisawa M . Injectable hydrogel systems crosslinked by horseradish peroxidase. Biomed Mater. 2015; 11(1):014101. DOI: 10.1088/1748-6041/11/1/014101. View

Korsmeyer R, Gurny R, Doelker E, Buri P, Peppas N . Mechanisms of potassium chloride release from compressed, hydrophilic, polymeric matrices: effect of entrapped air. J Pharm Sci. 1983; 72(10):1189-91. DOI: 10.1002/jps.2600721021. View

Zhou Z, Li G, Wang N, Guo F, Guo L, Liu X . Synthesis of temperature/pH dual-sensitive supramolecular micelles from β-cyclodextrin-poly(N-isopropylacrylamide) star polymer for drug delivery. Colloids Surf B Biointerfaces. 2018; 172:136-142. DOI: 10.1016/j.colsurfb.2018.08.031. View

McDermott M, Chen T, Williams C, Markley K, Payne G . Mechanical properties of biomimetic tissue adhesive based on the microbial transglutaminase-catalyzed crosslinking of gelatin. Biomacromolecules. 2004; 5(4):1270-9. DOI: 10.1021/bm034529a. View

10.

Gupta D, Santoso J, McCain M . Characterization of Gelatin Hydrogels Cross-Linked with Microbial Transglutaminase as Engineered Skeletal Muscle Substrates. Bioengineering (Basel). 2021; 8(1). PMC: 7825108. DOI: 10.3390/bioengineering8010006. View

11.

Liling G, Di Z, Jiachao X, Xin G, Xiaoting F, Qing Z . Effects of ionic crosslinking on physical and mechanical properties of alginate mulching films. Carbohydr Polym. 2015; 136:259-65. DOI: 10.1016/j.carbpol.2015.09.034. View

12.

Kuo C, Ma P . Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: part 1. Structure, gelation rate and mechanical properties. Biomaterials. 2001; 22(6):511-21. DOI: 10.1016/s0142-9612(00)00201-5. View

13.

Gierszewska M, Ostrowska-Czubenko J . Chitosan-based membranes with different ionic crosslinking density for pharmaceutical and industrial applications. Carbohydr Polym. 2016; 153:501-511. DOI: 10.1016/j.carbpol.2016.07.126. View

14.

Naseri N, Deepa B, Mathew A, Oksman K, Girandon L . Nanocellulose-Based Interpenetrating Polymer Network (IPN) Hydrogels for Cartilage Applications. Biomacromolecules. 2016; 17(11):3714-3723. DOI: 10.1021/acs.biomac.6b01243. View

15.

Chen R, Ho H, Sheu M . Characterization of collagen matrices crosslinked using microbial transglutaminase. Biomaterials. 2005; 26(20):4229-35. DOI: 10.1016/j.biomaterials.2004.11.012. View

16.

Berger J, Reist M, Mayer J, Felt O, Peppas N, Gurny R . Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. Eur J Pharm Biopharm. 2004; 57(1):19-34. DOI: 10.1016/s0939-6411(03)00161-9. View

17.

Liu Y, Wong C, Chang S, Hsu S . An injectable, self-healing phenol-functionalized chitosan hydrogel with fast gelling property and visible light-crosslinking capability for 3D printing. Acta Biomater. 2021; 122:211-219. DOI: 10.1016/j.actbio.2020.12.051. View

18.

Liu Y, Shu X, Prestwich G . Biocompatibility and stability of disulfide-crosslinked hyaluronan films. Biomaterials. 2005; 26(23):4737-46. DOI: 10.1016/j.biomaterials.2005.01.003. View

19.

Matricardi P, Di Meo C, Coviello T, Hennink W, Alhaique F . Interpenetrating Polymer Networks polysaccharide hydrogels for drug delivery and tissue engineering. Adv Drug Deliv Rev. 2013; 65(9):1172-87. DOI: 10.1016/j.addr.2013.04.002. View