Association Between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides Among Male Farmworkers in Northern Thailand

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2021 Oct 23

PMID 34682593

Citations 1

Authors

Neeranuch Suwannarin

Tippawan Prapamontol

Tomohiko Isobe

Yukiko Nishihama

Ampica Mangklabruks

Tawiwan Pantasri

Somporn Chantara

Warangkana Naksen

Shoji F Nakayama

Affiliations

Soon will be listed here.

Abstract

Exposure to insecticides may result in various health problems. This study investigated the association between haematological parameters and exposure to a mixture of organophosphate (OP) and neonicotinoid (NEO) insecticides among male farmworkers in Fang district, Chiang Mai province, northern Thailand. Concentrations of urinary dialkylphosphates, non-specific metabolites of OPs, and NEOs and their metabolites and haematological parameters were measured in 143 male farmworkers. The Bayesian kernel machine regression model was employed to evaluate the associations. Exposure to a mixture of insecticides was significantly associated with the mean corpuscular haemoglobin concentration (MCHC) when the concentrations of all the compounds and their metabolites were at the 60th percentile or higher compared with the 50th percentile. Furthermore, exposure to clothianidin (CLO) showed a decreasing association with MCHC when all the other insecticides were at their mean concentrations. CLO was the most likely compound to reduce MCHC, and this was confirmed by sensitivity analysis. These findings suggest that exposure to NEO insecticides, especially CLO, affects the haematological status relating to haemoglobin parameters.

Citing Articles

Associations between neonicotinoids and inflammation in US adults using hematological indices: NHANES 2015-2016.

Godbole A, Chen A, Vuong A Environ Epidemiol. 2024; 9(1):e358.

PMID: 39726632 PMC: 11671084. DOI: 10.1097/EE9.0000000000000358.

References

Zhang Q, Li Z, Chang C, Lou J, Zhao M, Lu C . Potential human exposures to neonicotinoid insecticides: A review. Environ Pollut. 2018; 236:71-81. DOI: 10.1016/j.envpol.2017.12.101. View

Koulnis M, Porpiglia E, Hidalgo D, Socolovsky M . Erythropoiesis: from molecular pathways to system properties. Adv Exp Med Biol. 2014; 844:37-58. DOI: 10.1007/978-1-4939-2095-2_3. View

Barr D, Bravo R, Weerasekera G, Caltabiano L, Whitehead Jr R, Olsson A . Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population. Environ Health Perspect. 2004; 112(2):186-200. PMC: 1241828. DOI: 10.1289/ehp.6503. View

Recio R, Ocampo-Gomez G, Moran-Martinez J, Borja-Aburto V, Lopez-Cervante M, Uribe M . Pesticide exposure alters follicle-stimulating hormone levels in Mexican agricultural workers. Environ Health Perspect. 2005; 113(9):1160-3. PMC: 1280395. DOI: 10.1289/ehp.7374. View

Tao Y, Phung D, Dong F, Xu J, Liu X, Wu X . Urinary monitoring of neonicotinoid imidacloprid exposure to pesticide applicators. Sci Total Environ. 2019; 669:721-728. DOI: 10.1016/j.scitotenv.2019.03.040. View

Sun H, Sun M, Barr D . Exposure to organophosphorus insecticides and increased risks of health and cancer in US women. Environ Toxicol Pharmacol. 2020; 80:103474. PMC: 7808295. DOI: 10.1016/j.etap.2020.103474. View

Zhang Y, Dong T, Hu W, Wang X, Xu B, Lin Z . Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: Comparison of three statistical models. Environ Int. 2018; 123:325-336. DOI: 10.1016/j.envint.2018.11.076. View

Piccoli C, Cremonese C, Koifman R, Koifman S, Freire C . Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil. Cien Saude Colet. 2019; 24(6):2325-2340. DOI: 10.1590/1413-81232018246.13142017. View

Sekhotha M, Monyeki K, Sibuyi M . Exposure to Agrochemicals and Cardiovascular Disease: A Review. Int J Environ Res Public Health. 2016; 13(2):229. PMC: 4772249. DOI: 10.3390/ijerph13020229. View

10.

Cremonese C, Piccoli C, Pasqualotto F, Clapauch R, Koifman R, Koifman S . Occupational exposure to pesticides, reproductive hormone levels and sperm quality in young Brazilian men. Reprod Toxicol. 2017; 67:174-185. DOI: 10.1016/j.reprotox.2017.01.001. View

11.

Bobb J, Claus Henn B, Valeri L, Coull B . Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression. Environ Health. 2018; 17(1):67. PMC: 6102907. DOI: 10.1186/s12940-018-0413-y. View

12.

Gonzalez-Alzaga B, Romero-Molina D, Lopez-Flores I, Gimenez-Asensio M, Hernandez A, Lacasana M . Urinary levels of organophosphate pesticides and predictors of exposure in pre-school and school children living in agricultural and urban communities from south Spain. Environ Res. 2020; 186:109459. DOI: 10.1016/j.envres.2020.109459. View

13.

Miranda-Contreras L, Gomez-Perez R, Rojas G, Cruz I, Berrueta L, Salmen S . Occupational exposure to organophosphate and carbamate pesticides affects sperm chromatin integrity and reproductive hormone levels among Venezuelan farm workers. J Occup Health. 2013; 55(3):195-203. DOI: 10.1539/joh.12-0144-fs. View

14.

Apidechkul T, Yeemard F, Chomchoei C, Upala P, Tamornpark R . Epidemiology of thalassemia among the hill tribe population in Thailand. PLoS One. 2021; 16(2):e0246736. PMC: 7877639. DOI: 10.1371/journal.pone.0246736. View

15.

Gaikwad A, Karunamoorthy P, Kondhalkar S, Ambikapathy M, Beerappa R . Assessment of hematological, biochemical effects and genotoxicity among pesticide sprayers in grape garden. J Occup Med Toxicol. 2015; 10:11. PMC: 4354760. DOI: 10.1186/s12995-015-0049-6. View

16.

Zhang T, Song S, Bai X, He Y, Zhang B, Gui M . A nationwide survey of urinary concentrations of neonicotinoid insecticides in China. Environ Int. 2019; 132:105114. DOI: 10.1016/j.envint.2019.105114. View

17.

Huang X, Zhang C, Hu R, Li Y, Yin Y, Chen Z . Association between occupational exposures to pesticides with heterogeneous chemical structures and farmer health in China. Sci Rep. 2016; 6:25190. PMC: 4846826. DOI: 10.1038/srep25190. View

18.

Osaka A, Ueyama J, Kondo T, Nomura H, Sugiura Y, Saito I . Exposure characterization of three major insecticide lines in urine of young children in Japan-neonicotinoids, organophosphates, and pyrethroids. Environ Res. 2016; 147:89-96. DOI: 10.1016/j.envres.2016.01.028. View

19.

Bobb J, Valeri L, Claus Henn B, Christiani D, Wright R, Mazumdar M . Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics. 2014; 16(3):493-508. PMC: 5963470. DOI: 10.1093/biostatistics/kxu058. View

20.

Kataria S, Chhillar A, Kumar A, Tomar M, Malik V . Cytogenetic and hematological alterations induced by acute oral exposure of imidacloprid in female mice. Drug Chem Toxicol. 2015; 39(1):59-65. DOI: 10.3109/01480545.2015.1026972. View